| Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. | |
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MedLine Citation:
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PMID: 19850110 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Alzheimer's disease (AD), the most prominent form of dementia in elderly, is a yet incurable degenerative neurological illness characterized by memory loss. Here, we used an AD rat model to investigate the in vivo efficacy of caprospinol, a disease-modifying steroid developed on the concept that reduced synthesis of 22R-hydroxycholesterol in the AD brain increases beta-amyloid neurotoxicity. Caprospinol treatment of diseased rats attenuated memory impairment, as assessed using Morris watermaze tests. This recovery of cognitive function was accompanied by a reduction in hippocampal amyloid deposits, astrogliosis, neurodegeneration and Tau protein phopshorylation. In parallel studies, caprospinol bioavailability in normal rat forebrain was found to be dependent on the dose and duration of the treatment, demonstrating the ability of the compound to cross the blood-brain barrier. These results position caprospinol as a promising drug candidate for AD treatment. |
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Authors:
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L Lecanu; G Rammouz; A McCourty; E K Sidahmed; J Greeson; V Papadopoulos |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience Volume: 165 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 427-35 Citation Subset: IM |
Affiliation:
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The Research Institute of the McGill University Health Centre, Department of Medicine, McGill University, Montreal, QC, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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