Document Detail


Capnellenes from the soft coral Dendronephthya rubeola.
MedLine Citation:
PMID:  18816521     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four new acetoxycapnellenes 1-4, the first epoxyprecapnellene 5, along with the known dihydroxycapnellene 6 and monoacetoxycapnellene 7, have been isolated from the soft coral Dendronephthya rubeola. The structures were determined primarily by NMR spectroscopy. The compounds 6 and 7 showed a good antiproliferative activity against the cell line L-929 (murine fibroblasts) and a good cytotoxic activity against the HeLa (human cervix carcinoma) cell line. Compound 6 strongly inhibits the interaction of the oncogenic transcription factor Myc with its partner protein Max. Myc/Max-Interaction inhibitors are therapeutically interesting compounds in oncology.
Authors:
Daniela Grote; Frank Hänel; Hans-Martin Dahse; Karlheinz Seifert
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  5     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1683-93     Citation Subset:  IM    
Affiliation:
Lehrstuhl für Organische Chemie, NW II, Universität Bayreuth, D-95440 Bayreuth.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthozoa / chemistry*
Cell Line, Tumor
Cell Survival / drug effects
Humans
Macrocyclic Compounds / chemistry*,  isolation & purification,  toxicity
Magnetic Resonance Spectroscopy
Molecular Structure
Spectrometry, Mass, Electrospray Ionization
Chemical
Reg. No./Substance:
0/Macrocyclic Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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