Document Detail

Capillary versus arterial plasma catecholamines as markers for sympatho-adrenal activity in infants.
MedLine Citation:
PMID:  1635819     Owner:  NLM     Status:  MEDLINE    
In this study, we investigated whether capillary plasma catecholamines can be used as a suitable substitute for arterial catecholamines. Analysis was done radioenzymatically. Catecholamine concentrations were not different in arterial and simultaneously collected "arterialized" (warmed foot) capillary plasma obtained by heel-prick from 18 neonatal intensive care patients as assessed by linear regression analysis (correlation coefficient: 0.966 for noradrenaline; 0.894 for adrenaline; p less than 0.05) and by a Wilcoxon test [noradrenaline: 2.13 (0.61-10.47) versus 2.41 (1.05-10.23); adrenaline: 0.75 (0.16-1.70) versus 0.72 (0.10-1.37) nmol/L, median (range)]. However, "arterialization" of capillary blood is important; when blood was obtained in nine neonates without warming their feet, capillary concentrations of noradrenaline were higher than arterial values (p less than 0.03) and those of adrenaline were not different from arterial values. Catecholamine concentrations in arterialized capillary plasma collected in healthy full-term infants at 1 h [n = 9; noradrenaline: 6.85 (3.09-8.88) nmol/L; adrenaline: 1.34 (0.86-2.85) nmol/L] and 5 d after birth [n = 27; noradrenaline: 1.58 (0.89-3.16) nmol/L; adrenaline: 0.59 (0.25-1.64) nmol/L] reflect the well-known fall (p less than 0.01) in catecholamine levels after delivery. With a highly sensitive analytical technique, catecholamine concentrations can reliably be assessed in minute samples (100-200 microL) of arterialized capillary blood, even when concentrations have dropped to low "resting" basal levels. Moreover, the capillary sampling procedure is simple and safe, can easily be applied to healthy infants, and does not have the practical and ethical limitations of arterial blood sampling.
H Baumgartner; R Ritsch; O Luz; J Schneeberger; I Hammerer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  31     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-26     Completed Date:  1992-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  579-82     Citation Subset:  IM    
Institut für Biochemische Pharmakologie, Universität Innsbruck, Austria.
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MeSH Terms
Adrenal Glands / physiology*
Biological Markers
Blood Specimen Collection
Catecholamines / blood*
Epinephrine / blood
Infant, Newborn
Norepinephrine / blood
Sympathetic Nervous System / physiology*
Reg. No./Substance:
0/Biological Markers; 0/Catecholamines; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

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