| Capillary and venous samples of total creatine kinase are similar after eccentric exercise. | |
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MedLine Citation:
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PMID: 21132860 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Circulating creatine kinase (CK) levels are often monitored as an indirect biomarker of muscle damage after resistive exercise. The purpose of the present investigation was to evaluate whether capillary whole-blood sampling, a simpler and less invasive method for obtaining a venous blood sample, would allow for a reliable measurement of total CK compared to venipuncture. Fifteen untrained subjects performed 50 maximal eccentric elbow extensions to induce muscle damage of the biceps brachii. Capillary (fingerstick) and venous whole-blood samples were collected contemporaneously at baseline and again at 24, 48, 72, and 96 hours post-exercise. Using a commercial CK analysis kit with a protocol modification to account for a reduced sample size, total CK activity of the capillary and venous samples was analyzed concurrently via spectrophotometry. Results indicated a 0.997 correlation between sampling sites for total CK, with disagreement between the venous and capillary samples estimated at <12% across the range of CK values. These findings indicate capillary sampling for total CK activity provides a valid alternative to venipuncture and should be considered by researchers, clinicians, and strength and conditioning specialists as an alternate sampling technique when indirectly evaluating muscle damage after exercise. |
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Authors:
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Mark A Knoblauch; Daniel P O'Connor; Mark S F Clarke |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of strength and conditioning research / National Strength & Conditioning Association Volume: 24 ISSN: 1533-4287 ISO Abbreviation: J Strength Cond Res Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9415084 Medline TA: J Strength Cond Res Country: United States |
Other Details:
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Languages: eng Pagination: 3471-5 Citation Subset: IM |
Affiliation:
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Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, Texas, USA. maknoblauch@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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