Document Detail

Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment.
MedLine Citation:
PMID:  9779722     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of our study was to elucidate whether the fluid retention syndrome induced by docetaxel is caused by capillary protein leakage or by other mechanisms.
PATIENTS AND METHODS: Twenty-four patients with advanced or metastatic non-small-cell lung cancer (NSCLC; 23 patients) or metastatic head and neck cancer (one patient) were included on this prospective, nonrandomized trial. Docetaxel 100 mg/m2 was administered every 3 weeks with 5 days of dexamethasone prophylaxis to avoid hypersensitivity reactions and edema formation. Transcapillary forces, ie, colloid osmotic pressure of plasma (COPpl) and interstitial fluid (COPint) and interstitial hydrostatic pressure (Pint), were measured before the start of treatment and after total docetaxel doses of 200 and 500 mg/m2 by means of the well-documented wick and wick-in-needle methods. Body weight, degree of edema, blood pressure, and heart rate and hemoglobin, hematocrit, albumin, and total protein values were registered in parallel.
RESULTS: After a total docetaxel dose of 200 mg/m2, COPpl, COPint, and hemoglobin, hematocrit, albumin, and total protein values had decreased significantly; Pint and body weight were unchanged; and only mild edema was observed. These findings suggest a plasma volume increase followed by enhanced fluid filtration to the interstitium. After a cumulative docetaxel dose of 500 mg/m2, the COPpl continued to decrease significantly, but COPint remained unchanged despite a significant increase in mean body weight and edema formation. These observations support the theory of a capillary protein leakage.
CONCLUSION: Docetaxel appears to induce an initial enhancement of fluid filtration followed by a capillary protein leakage that leads to edema formation.
K A Semb; S Aamdal; P Oian
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  16     ISSN:  0732-183X     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-10-26     Completed Date:  1998-10-26     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3426-32     Citation Subset:  IM    
Department of Oncology, The Norwegian Radium Hospital, Oslo.
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MeSH Terms
Antineoplastic Agents, Phytogenic / adverse effects*
Body Weight
Capillary Leak Syndrome / chemically induced*,  complications
Capillary Permeability
Carcinoma, Non-Small-Cell Lung / drug therapy*
Edema / etiology*
Hemodynamics / drug effects
Lung Neoplasms / drug therapy*
Paclitaxel / adverse effects,  analogs & derivatives*
Prospective Studies
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Taxoids; 15H5577CQD/docetaxel; 33069-62-4/Paclitaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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