Document Detail


Capillary neoformation in the rat heart--stereological studies on papillary muscles in hypertrophy and physiologic growth.
MedLine Citation:
PMID:  1706178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stereological investigations on myocardial capillaries provided evidence that the common estimator of capillarity, the capillary density (i.e., number of capillary profiles per unit transverse sectional area), underestimates the true capillary supply since the capillary axes are not oriented perfectly in parallel to the myofiber axes. Recently, we studied the "true" capillarity, i.e., the length density of capillaries (LV = capillary length per capillary volume), in some experimental models of cardiac hypertrophy which have been published elsewhere. It has been shown that LV decreases in renovascular hypertension, but is maintained in physical exercise and after chronic thyroxin application. However, the growth pattern of capillaries in hypertrophic hearts has not yet been analyzed. In the present paper it is demonstrated that important information on the capillary network can be derived from the two-dimensional capillary-to-fiber ratios (2D CFR: capillary profiles per myofiber profiles in transverse sections) and from the three-dimensional capillary-to-fiber ratios (3D CFR: capillary length per unit myofiber length). Increase in both suggests neoformation of additional capillary branches in parallel connection. Retrospective analysis of the quantitative data indicates that in hypertrophy induced by physical exercise or by chronic thyroxin application capillary neoformation in parallel connection counterbalances increase of oxygen diffusion distance due to myofiber enlargement. In renovascular hypertension, capillary neoformation in parallel connection does not occur. Studies on normal growth indicated both a slight decrease of LV of capillaries, as well as a continuous neoformation of additional capillary branches.
Authors:
G Mall; G Zimmer; S Baden; T Mattfeldt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Basic research in cardiology     Volume:  85     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1990 Nov-Dec
Date Detail:
Created Date:  1991-04-18     Completed Date:  1991-04-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  531-40     Citation Subset:  IM    
Affiliation:
Pathologisches Institut, Universität Heidelberg, FRG.
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillaries
Cardiomegaly / chemically induced,  pathology*
Coronary Circulation*
Female
Hypertension, Renovascular / physiopathology
Male
Muscle Development
Neovascularization, Pathologic / pathology*
Papillary Muscles / growth & development,  pathology*
Physical Exertion
Rats
Rats, Inbred Strains
Thyroxine
Chemical
Reg. No./Substance:
7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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