Document Detail

Capillary hemangioma of the central nervous system.
MedLine Citation:
PMID:  15255254     Owner:  NLM     Status:  MEDLINE    
OBJECT: Capillary hemangiomas are benign tumors or tumorlike lesions that originate from blood vessels and have rarely been reported to develop in the brain or spinal cord. The authors summarize the clinical and histological features of capillary hemangiomas of the central nervous system (CNS). METHODS: The clinical features, imaging characteristics, and outcomes in 10 patients with CNS capillary hemangiomas were reviewed. Histological studies included immunostaining with CD31, alpha-smooth muscle actin, vascular endothelial growth factor, and Ki-67 antigen. Three patients with lesions in the brain presented with symptoms of increased intracranial pressure or seizures. Seven patients with lesions in the spinal cord presented with progressive sensorimotor disturbances of the lower limbs. Computerized tomography and magnetic resonance imaging demonstrated well-defined, enhancing lesions associated with marked perifocal edema. Angiography demonstrated hypervascular lesions, which have not recurred after resection. In two cases, multiple satellite lesions resolved after the systemic administration of steroid drugs or interferon-alpha. Histologically, all lesions were consistent with findings of capillary hemangioma of the skin or soft tissues. The CNS lesions differed significantly from other vascular neoplasms, such as hemangioendotheliomas, hemangiopericytomas, and hemangioblastomas. CONCLUSIONS: Capillary hemangiomas of the CNS are benign lesions that can be surgically removed and cured without adjuvant therapy.
Masamitsu Abe; Kazuo Tabuchi; Shin Tanaka; Akira Hodozuka; Katsuzo Kunishio; Naohiko Kubo; Yukimasa Nishimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  101     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-16     Completed Date:  2004-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-81     Citation Subset:  AIM; IM    
Department of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan.
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MeSH Terms
Aged, 80 and over
Brain Neoplasms / pathology*,  radiography,  surgery
Central Nervous System Vascular Malformations / pathology
Diagnosis, Differential
Hemangioma, Capillary / pathology*,  radiography,  surgery
Middle Aged
Retrospective Studies
Spinal Cord Neoplasms / pathology*,  radiography,  surgery
Thoracic Vertebrae
Treatment Outcome
Vascular Neoplasms / pathology

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