Document Detail


Capillary embolization using ethiodol-ethanol for complete renal ablation in Swine.
MedLine Citation:
PMID:  12218447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: To evaluate the effect of capillary embolization with superselectively administered 1:1 Ethiodol-ethanol mixture (EEM) for complete nephrectomy in normal porcine kidneys. MATERIALS AND METHODS: One kidney in each animal was completely embolized by sequential segmental arterial injections of the EEM via a microcatheter until complete capillary stasis occurred. Group 1 (n = 5): Initial embolization did not occlude the arterial compartment. Group 2 (n = 7): The capillary embolization was performed in conjunction with absolute ethanol injection and coil placement during balloon catheter occlusion. RESULTS: Group 1: Complete recanalization occurred following the EEM embolization (1-week). After the repeat embolization (EEM + pure ethanol without balloon occlusion), three of five kidneys showed partial recanalization (2-weeks). Following a third embolization (EEM + coil) in two pigs, one kidney showed partial recanalization (12-weeks). Group 2: Complete renal artery occlusion was achieved in all kidneys with no recanalization. Histologically, four kidneys exhibited total ablation whereas three showed minimal preexisting parenchyma (8-weeks). CONCLUSIONS: Permanent arterial occlusion with histologically complete renal ablation was achieved using a two-phase technique of homogeneous capillary embolization with 1:1 EEM and ethanol and coil occlusion performed during temporary balloon occlusion. Sequential segmental EEM injections alone did not produce permanent capillary embolization.
Authors:
Andras Konya; Kenneth C Wright
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative radiology     Volume:  37     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-09     Completed Date:  2002-10-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  512-20     Citation Subset:  IM    
Affiliation:
Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. akonya@mdanderson.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillaries
Embolization, Therapeutic*
Ethanol / administration & dosage
Ethiodized Oil / administration & dosage
Kidney / blood supply,  drug effects*,  pathology
Models, Animal
Nephrectomy / methods*
Renal Artery* / radiography
Swine
Time Factors
Grant Support
ID/Acronym/Agency:
CA-16672/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol; 8008-53-5/Ethiodized Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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