Document Detail

Capillary electrophoresis in analysis of veterinary drugs.
MedLine Citation:
PMID:  12899980     Owner:  NLM     Status:  MEDLINE    
Antibiotics are extensively applied in veterinary medicine for the treatment of various bacterial infections. Because of their use in food producing animals, the risk of occurrence of unwanted residues in edible products exists. To ensure human food safety, The European Union has defined maximum residue limits (MRLs) for veterinary drug residues in food products. Analytical methods need to be developed to confirm the presence of antibiotics at the MRL level. A capillary electrophoresis (CE) method with UV detection is proposed for the quantitative determination of residues from poultry and porcine tissues. Eight of the most frequently used antibiotics and nifursol, which routinely used as poultry coccidiostat, were analysed. CE technique permitted analysing substances to be separated from muscle, liver, kidney and skin with fat after a simple extraction with acetonitrile or ethyl acetate under basic conditions. Proposed method is capable to identify drug residues in tissues at level below 20 microg/kg.
P Kowalski; I Oledzka; H Lamparczyk
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  32     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-05     Completed Date:  2004-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  937-47     Citation Subset:  IM    
Medical University of Gdańsk, Hallera 107, PL-80-416 Gdansk, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Electrophoresis, Capillary / methods
Technology, Pharmaceutical / methods*
Tissue Distribution / physiology
Veterinary Drugs / analysis*,  metabolism*
Reg. No./Substance:
0/Veterinary Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Photochemical degradation of solid-state nisoldipine monitored by HPLC.
Next Document:  Determination of ursodeoxycholic acid in pharmaceutical preparations by capillary electrophoresis wi...