Document Detail


Capillary Remodeling in Infants Born to Hypertensive Pregnancy: Pilot Study.
MedLine Citation:
PMID:  22573013     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BackgroundCapillary rarefaction is pathognomonic of essential hypertension. We have previously shown significant capillary rarefaction in normotensive adult offspring of hypertensive parents, suggesting a familial predisposition in which capillary rarefaction represents a primary vascular abnormality that antedates the onset of sustained elevation of blood pressure (BP). We have recently reported that low-birth weight (LBW) infants, born at term or preterm, to normotensive mothers do not have capillary rarefaction at birth. We hypothesized that infants born to mothers with hypertensive disorders of pregnancy (HDP) would have significant capillary rarefaction at birth when compared to infants of normotensive mothers.MethodsWe studied 22 infants born to hypertensive mothers and compared them to 40 normal birth weight infants born at term to normotensive mothers. We used orthogonal polarized spectroscopy to measure basal (i.e., functional) and maximal (i.e., structural) skin capillary densities according to a well-validated protocol.ResultsWe found that term infants born to hypertensive mothers had significantly lower maximal capillary density (MCD) (mean difference of -5.0 capillaries/mm(2); P < 0.05). However, preterm infants with LBW born to hypertensive mothers tended to have higher basal and maximal skin capillary densities compared with term infants.ConclusionsWhile the results in term infants are consistent with our belief that capillary rarefaction in essential hypertension is likely to be a primary vascular abnormality, the results in preterm infants may suggest that the intrauterine environment may exert some influences on the remodeling of the microcirculation which may delay the onset of capillary rarefaction in these infants.American Journal of Hypertension 2012; doi:10.1038/ajh.2012.51.
Authors:
Tarek F T Antonios; Rajendra P Raghuraman; Rohan D'Souza; Preetha Nathan; Duolao Wang; Isaac T Manyonda
Related Documents :
8414743 - Association between pulmonary and gastric inflammatory cells on the first day of life i...
9536833 - Randomised trial of erythromycin on the development of chronic lung disease in preterm ...
16581603 - Neighborhood deprivation and preterm birth in plymouth, uk.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-10
Journal Detail:
Title:  American journal of hypertension     Volume:  -     ISSN:  1941-7225     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Blood Pressure Unit & Department of Clinical Sciences, St. George's, University of London, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Blood pressure indexes and end-stage renal disease risk in adults with chronic kidney disease.
Next Document:  Association of Several Lipid-Related Gene Polymorphisms and Blood Pressure Variation in the Bai Ku Y...