Document Detail

Capillaritis associated with interferon-alfa treatment of chronic hepatitis C infection.
MedLine Citation:
PMID:  11044828     Owner:  NLM     Status:  MEDLINE    
We report the case of a 36-year-old man who was referred with an asymptomatic eruption that started on both lower legs. This started shortly after being commenced on interferon-alfa for chronic hepatitis secondary to hepatitis C. Clinically, the eruption was consistent with a capillaritis (pigmented purpuric dermatosis). Histology confirmed this to be lymphocytic vasculitis. Lymphocytic vasculitis is frequently identified in the salivary glands of patients who are hepatitis C positive. Although leukocytoclastic vasculitis confined to the skin is frequently reported with hepatitis C, lymphocytic vasculitis is rarely reported. We consider that the lymphocytic vasculitis in our patient occurred as a result of interferon-alfa treatment because of the strong temporal relationship between the onset of the skin eruption and drug therapy.
G Gupta; S C Holmes; E Spence; P R Mills
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  43     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-04-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-8     Citation Subset:  IM    
Department of Dermatology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK.
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MeSH Terms
Antiviral Agents / adverse effects*,  therapeutic use
Hepatitis C, Chronic / drug therapy*
Histiocytes / pathology
Interferon-alpha / adverse effects*,  therapeutic use
Lymphocytes / pathology
Skin / pathology
Skin Diseases, Vascular / chemically induced*,  pathology
Vasculitis / chemically induced*,  pathology
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha

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