| Capillaritis associated with interferon-alfa treatment of chronic hepatitis C infection. | |
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MedLine Citation:
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PMID: 11044828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a 36-year-old man who was referred with an asymptomatic eruption that started on both lower legs. This started shortly after being commenced on interferon-alfa for chronic hepatitis secondary to hepatitis C. Clinically, the eruption was consistent with a capillaritis (pigmented purpuric dermatosis). Histology confirmed this to be lymphocytic vasculitis. Lymphocytic vasculitis is frequently identified in the salivary glands of patients who are hepatitis C positive. Although leukocytoclastic vasculitis confined to the skin is frequently reported with hepatitis C, lymphocytic vasculitis is rarely reported. We consider that the lymphocytic vasculitis in our patient occurred as a result of interferon-alfa treatment because of the strong temporal relationship between the onset of the skin eruption and drug therapy. |
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Authors:
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G Gupta; S C Holmes; E Spence; P R Mills |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 43 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-04-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 937-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiviral Agents / adverse effects*, therapeutic use Hepatitis C, Chronic / drug therapy* Histiocytes / pathology Humans Interferon-alpha / adverse effects*, therapeutic use Lymphocytes / pathology Male Skin / pathology Skin Diseases, Vascular / chemically induced*, pathology Vasculitis / chemically induced*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Interferon-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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