| Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. | |
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MedLine Citation:
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PMID: 17398096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Signaling via the receptor tyrosine kinase (RTK)/Ras pathway promotes tissue growth during organismal development and is increased in many cancers [1]. It is still not understood precisely how this pathway promotes cell growth (mass accumulation). In addition, the RTK/Ras pathway also functions in cell survival, cell-fate specification, terminal differentiation, and progression through mitosis [2-7]. An important question is how the same canonical pathway can elicit strikingly different responses in different cell types. Here, we show that the HMG-box protein Capicua (Cic) restricts cell growth in Drosophila imaginal discs, and its levels are, in turn, downregulated by Ras signaling. Moreover, unlike normal cells, the growth of cic mutant cells is undiminished in the complete absence of a Ras signal. In addition to a general role in growth regulation, the importance of cic in regulating cell-fate determination downstream of Ras appears to vary from tissue to tissue. In the developing eye, the analysis of cic mutants shows that the functions of Ras in regulating growth and cell-fate determination are separable. Thus, the DNA-binding protein Cic is a key downstream component in the pathway by which Ras regulates growth in imaginal discs. |
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Authors:
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Ai-Sun Kelly Tseng; Nicolas Tapon; Hiroshi Kanda; Seden Cigizoglu; Lambert Edelmann; Brett Pellock; Kristin White; Iswar K Hariharan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-03-29 |
Journal Detail:
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Title: Current biology : CB Volume: 17 ISSN: 0960-9822 ISO Abbreviation: Curr. Biol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-17 Completed Date: 2007-10-03 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: England |
Other Details:
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Languages: eng Pagination: 728-33 Citation Subset: IM |
Affiliation:
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Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation Drosophila / cytology*, growth & development, metabolism* Drosophila Proteins / genetics, metabolism* Eye / cytology, embryology, growth & development HMGB Proteins Receptor Protein-Tyrosine Kinases / metabolism* Repressor Proteins / genetics, metabolism* Signal Transduction* ras Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM 55568/GM/NIGMS NIH HHS; R01 GM061672-05/GM/NIGMS NIH HHS; R01 GM061672-06/GM/NIGMS NIH HHS; R01 GM61672/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/HMGB Proteins; 0/Repressor Proteins; 0/cic protein, Drosophila; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 3.6.5.2/ras Proteins |
| Comments/Corrections | |
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