| Capecitabine-related intracranial hypotension syndrome mimicking dural metastasis in a breast cancer patient: Case report and review of the literature. | |
| | |
MedLine Citation:
|
PMID: 21358101 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Spontaneous intracranial hypotension (SICH) is an entity, which is secondary to iatrogenic manipulation and breaching of dura. Postural headache in patients should be suspected, cranial magnetic resonance imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is regular shape of pachymeningeal gadolinium enhancement and subdural effusion. It may mimic central nervous system (CNS) metastasis. Prevention of such cases from receiving cranial radiotherapy by misinterpretation of the gadolinium enhancement as CNS metastasis is an important issue. Capecitabine is an antineoplastic agent, of which metabolites can cross blood-brain barrier in CNS via epithelial tissue. It may cause decrease in CSF production. SICH might be the clinical reflection of this decrease in CSF production. Review of the English literature revealed limited data because of the very little experience with oncologic patients suffering from intracranial hypotension. We report a case of spontaneous intracranial hypotension during capecitabine treatment. Patient was completely well following drug discontinuation and supportive treatment. |
| | |
Authors:
|
Rusen Cosar-Alas; Aykan Alas; Alaattin Ozen; Bengu Denizli; Mert Saynak; Sernaz Uzunoglu; Nurettin Aydogdu; Hakan Karagol; Cem Uzal; Zafer Kocak |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cancer research and therapeutics Volume: 6 ISSN: 1998-4138 ISO Abbreviation: J Cancer Res Ther Publication Date: 2010 Oct-Dec |
Date Detail:
|
Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101249598 Medline TA: J Cancer Res Ther Country: India |
Other Details:
|
Languages: eng Pagination: 557-9 Citation Subset: IM |
Affiliation:
|
Department of Radiation Oncology, Trakya University Medical Faculty, Edirne, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Unusual clinical and radiological presentation of metastatic choriocarcinoma to the brain and long-t...
Next Document: Cystic angiomatous meningioma in the cerebellopontine angle mimicking hemangioblastoma.