Document Detail

Capecitabine may induce coronary artery vasospasm.
MedLine Citation:
PMID:  22796820     Owner:  NLM     Status:  MEDLINE    
Capecitabine is a new oral chemotherapeutic agent that is considered highly specific for sensitive tumor cells. We present the case of a patient who, after treatment with capecitabine for colorectal cancer, presented to our hospital with angina pectoris and electrocardiographic changes indicative of myocardial ischemia. The absence of epicardial coronary stenosis on the coronary angiogram ruled out atherosclerotic coronary disease as the cause of ischemia. The occurrence of coronary spasm, although not evident during coronary angiography, seems to be a possible explanation of the patient's symptoms.
Eleutherios Tsiamis; Andreas Synetos; Christodoulos Stefanadis
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hellenic journal of cardiology : HJC = Hellēnikē kardiologikē epitheōrēsē     Volume:  53     ISSN:  2241-5955     ISO Abbreviation:  Hellenic J Cardiol     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-12-11     Revised Date:  2014-01-21    
Medline Journal Info:
Nlm Unique ID:  101257381     Medline TA:  Hellenic J Cardiol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  320-3     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris / chemically induced,  diagnosis
Antibiotics, Antineoplastic / administration & dosage
Antimetabolites, Antineoplastic / administration & dosage,  adverse effects*
Colorectal Neoplasms / drug therapy*
Coronary Angiography
Coronary Vasospasm / chemically induced*,  diagnosis
Deoxycytidine / administration & dosage,  adverse effects,  analogs & derivatives*
Doxorubicin / administration & dosage
Drug Therapy, Combination
Fluorouracil / administration & dosage,  adverse effects,  analogs & derivatives*
Middle Aged
Myocardial Ischemia / chemically induced,  diagnosis
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antimetabolites, Antineoplastic; 0W860991D6/Deoxycytidine; 6804DJ8Z9U/capecitabine; 80168379AG/Doxorubicin; U3P01618RT/Fluorouracil
Comment In:
Hellenic J Cardiol. 2013 Nov-Dec;54(6):482-5   [PMID:  24305588 ]

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