Document Detail


Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases.
MedLine Citation:
PMID:  23038659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Capecitabine has shown significant antitumor activity against anthracycline/taxane refractory breast cancer and advanced colorectal carcinoma. The main drug-related adverse effects are palmar-plantar erythrodysesthesia (hand-foot syndrome), diarrhea and stomatitis. Dyslipidemia is a rare but important side effect of this drug. The mechanism of capecitabine-induced hypertriglyceridemia (CI-HTG) is unclear. It may be due to the decreased activities of lipoprotein lipase and hepatic triglyceride lipase. This report is associated with 2 patients who developed severe HTG when receiving capecitabine. Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels. This report describes CI-HTG and possible pathogenetic mechanisms and the literature is reviewed.
Authors:
Berna Bozkurt Duman; Semra Paydas; Tamer Tetiker; Meral Gunaldı; Cigdem Usul Afsar; Vehbi Erçolak; Veysel Haksöyler; Merve Şimşek Dilli
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-09-13
Journal Detail:
Title:  Pharmacology     Volume:  90     ISSN:  1423-0313     ISO Abbreviation:  Pharmacology     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-05     Completed Date:  2013-04-22     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  212-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Cukurova University Medical Faculty Departments of Medical Oncology, Balcalı Hospital, Adana, Turkey. berboz@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Antimetabolites, Antineoplastic / adverse effects*
Deoxycytidine / adverse effects,  analogs & derivatives*
Female
Fluorouracil / adverse effects,  analogs & derivatives*
Humans
Hyperglycemia / chemically induced*
Hypertriglyceridemia / chemically induced*
Middle Aged
Chemical
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 51-21-8/Fluorouracil; 6804DJ8Z9U/capecitabine; 951-77-9/Deoxycytidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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