| Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases. | |
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MedLine Citation:
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PMID: 23038659 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Capecitabine has shown significant antitumor activity against anthracycline/taxane refractory breast cancer and advanced colorectal carcinoma. The main drug-related adverse effects are palmar-plantar erythrodysesthesia (hand-foot syndrome), diarrhea and stomatitis. Dyslipidemia is a rare but important side effect of this drug. The mechanism of capecitabine-induced hypertriglyceridemia (CI-HTG) is unclear. It may be due to the decreased activities of lipoprotein lipase and hepatic triglyceride lipase. This report is associated with 2 patients who developed severe HTG when receiving capecitabine. Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels. This report describes CI-HTG and possible pathogenetic mechanisms and the literature is reviewed. |
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Authors:
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Berna Bozkurt Duman; Semra Paydas; Tamer Tetiker; Meral Gunaldı; Cigdem Usul Afsar; Vehbi Erçolak; Veysel Haksöyler; Merve Şimşek Dilli |
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Publication Detail:
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Type: Journal Article Date: 2012-09-13 |
Journal Detail:
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Title: Pharmacology Volume: 90 ISSN: 1423-0313 ISO Abbreviation: Pharmacology Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 212-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Cukurova University Medical Faculty Departments of Medical Oncology, Balcalı Hospital, Adana, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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