Document Detail

Capasaicin induced deafferentation enhances the effect of electrical vagal nerve stimulation on food intake and body mass.
MedLine Citation:
PMID:  15082875     Owner:  NLM     Status:  MEDLINE    
Study was based on hypothesis that electrical stimulation (ES) with parameters obtained from analysis of vagal afferent discharge fed state may fake brain with satiety state. We evaluated effect of denervation of vagal capsaicin-sensitive afferents on food intake and body weight in rats with ES of vagal nerves using microchip (MC). Group A was scheduled to MC implantation, B to sham operation only, C to MC implantation and capsaicin vagal deafferentation, and D to capsaicin denervation only. ES lasted 24 days. MC parameters were 0.05 Hz, 0.1s, 0.55 V. ES of left vagus significantly reduced total food intake as well as the mean daily intake in groups A and C in comparison to control and D group (ANOVA, F=18.55, p=0.0038). Body weight was lower in group A (3462 g) and C (2727 g) then in control (3814 g) and D (3568 g) (F=25.68, p=0.00068). Leptin decreased in C (165 pg/mL) in comparison to A (625 pg/mL), B (677 pg/mL), and D (612 pg/mL) (p<0,05), mainly due to ES (F=7.27, p=0.019). Glucose was decreased in A (F=5.55, p=0.036) - by 11% and by 16% in C group. Proper vagal neuromodulation results in central and peripheral effects causing food intake and body weight downregulation.
J Laskiewicz; G Królczyk; D Zurowski; P Enck; P J Thor
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  55     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-14     Completed Date:  2004-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
Department of Pathophysiology, Jagiellonian University, Cracow, Poland.
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MeSH Terms
Administration, Topical
Afferent Pathways / drug effects*,  injuries,  physiopathology
Blood Glucose / drug effects,  metabolism
Body Weight / drug effects,  physiology*
Capsaicin / pharmacology*
Down-Regulation / drug effects,  physiology
Eating / drug effects,  physiology*
Electric Stimulation / methods*
Fasting / physiology
Insulin / blood
Leptin / blood
Microchemistry / methods
Rats, Wistar
Vagus Nerve / drug effects,  physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Leptin; 11061-68-0/Insulin; 404-86-4/Capsaicin

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