| Capasaicin induced deafferentation enhances the effect of electrical vagal nerve stimulation on food intake and body mass. | |
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MedLine Citation:
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PMID: 15082875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Study was based on hypothesis that electrical stimulation (ES) with parameters obtained from analysis of vagal afferent discharge fed state may fake brain with satiety state. We evaluated effect of denervation of vagal capsaicin-sensitive afferents on food intake and body weight in rats with ES of vagal nerves using microchip (MC). Group A was scheduled to MC implantation, B to sham operation only, C to MC implantation and capsaicin vagal deafferentation, and D to capsaicin denervation only. ES lasted 24 days. MC parameters were 0.05 Hz, 0.1s, 0.55 V. ES of left vagus significantly reduced total food intake as well as the mean daily intake in groups A and C in comparison to control and D group (ANOVA, F=18.55, p=0.0038). Body weight was lower in group A (3462 g) and C (2727 g) then in control (3814 g) and D (3568 g) (F=25.68, p=0.00068). Leptin decreased in C (165 pg/mL) in comparison to A (625 pg/mL), B (677 pg/mL), and D (612 pg/mL) (p<0,05), mainly due to ES (F=7.27, p=0.019). Glucose was decreased in A (F=5.55, p=0.036) - by 11% and by 16% in C group. Proper vagal neuromodulation results in central and peripheral effects causing food intake and body weight downregulation. |
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Authors:
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J Laskiewicz; G Królczyk; D Zurowski; P Enck; P J Thor |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 55 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-04-14 Completed Date: 2004-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 155-63 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Jagiellonian University, Cracow, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Afferent Pathways / drug effects*, injuries, physiopathology Animals Blood Glucose / drug effects, metabolism Body Weight / drug effects, physiology* Capsaicin / pharmacology* Denervation Down-Regulation / drug effects, physiology Eating / drug effects, physiology* Electric Stimulation / methods* Fasting / physiology Insulin / blood Leptin / blood Male Microchemistry / methods Rats Rats, Wistar Vagus Nerve / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Leptin; 11061-68-0/Insulin; 404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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