Document Detail

The Cantrell-sequence: a result of maternal exposure to aminopropionitriles?
MedLine Citation:
PMID:  9394169     Owner:  NLM     Status:  MEDLINE    
The characteristic features of the Cantrell-sequence--anterior thoraco-abdominal wall defect with ectopia cordis and diaphragm, sternum, pericardium, and heart defects--have been observed in animals following maternal administration of beta-aminopropionitrile, a toxic amino-acid derivative. We report on an unusual case of the Cantrell-sequence in a premature infant with associated dysmelia, aplasia of the right kidney, cerebellar hypoplasia and circumscribed aplasia of the cutis, which has not been reported previously. Maternal history suggested an occupational exposure to aminopropionitriles prior to pregnancy. Prenatal ultrasound, differential diagnosis, perinatal management, and the teratogenic role of aminopropionitriles in this rare genetic disorder are discussed.
J Dembinski; W Heyl; K Steidel; B Hermanns; H Hörnchen; W Schröder
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of perinatology     Volume:  14     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-02-10     Completed Date:  1998-02-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  567-71     Citation Subset:  IM    
Department of Pediatrics, RWTH Technical University of Aachen, Germany.
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MeSH Terms
Abnormalities, Multiple / etiology*
Aminopropionitrile / adverse effects*
Fatal Outcome
Infant, Newborn
Occupational Exposure / adverse effects*
Pregnancy Complications / diagnosis*,  etiology
Prenatal Exposure Delayed Effects*
Reg. No./Substance:

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