| The Cantrell-sequence: a result of maternal exposure to aminopropionitriles? | |
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MedLine Citation:
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PMID: 9394169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The characteristic features of the Cantrell-sequence--anterior thoraco-abdominal wall defect with ectopia cordis and diaphragm, sternum, pericardium, and heart defects--have been observed in animals following maternal administration of beta-aminopropionitrile, a toxic amino-acid derivative. We report on an unusual case of the Cantrell-sequence in a premature infant with associated dysmelia, aplasia of the right kidney, cerebellar hypoplasia and circumscribed aplasia of the cutis, which has not been reported previously. Maternal history suggested an occupational exposure to aminopropionitriles prior to pregnancy. Prenatal ultrasound, differential diagnosis, perinatal management, and the teratogenic role of aminopropionitriles in this rare genetic disorder are discussed. |
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Authors:
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J Dembinski; W Heyl; K Steidel; B Hermanns; H Hörnchen; W Schröder |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: American journal of perinatology Volume: 14 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1998-02-10 Completed Date: 1998-02-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 567-71 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, RWTH Technical University of Aachen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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etiology* Adult Aminopropionitrile / adverse effects* Fatal Outcome Female Humans Infant, Newborn Occupational Exposure / adverse effects* Pregnancy Pregnancy Complications / diagnosis*, etiology Prenatal Exposure Delayed Effects* |
| Chemical | |
Reg. No./Substance:
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151-18-8/Aminopropionitrile |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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