| Canthaxanthin. | |
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MedLine Citation:
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PMID: 3934089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Canthaxanthin is used as a food-coloring agent, a photoprotective agent in certain photodermatoses, a tan-simulating agent, and a pigment to darken vitiliginous skin. This article reviews the current literature on canthaxanthin and reports the evaluation of oral canthaxanthin as an artificial pigment for the management of vitiligo. Fifty-six patients were studied, using serum canthaxanthin levels, pre- and post-treatment photographs with standard conditions, physician assessment, and patient questionnaires evaluating treatment results. Canthaxanthin was rated "very satisfactory" by 10%, "satisfactory" by 35%, and "unsatisfactory" by 54% of patients. In light-skinned individuals, self-reports were "very satisfactory" in 27%, "satisfactory" in 45%, and "unsatisfactory" in 27%. In dark-skinned individuals, the treatment was less effective. Women were happier with the results than men. Major side effects were red stools and orange palms and soles. Canthaxanthin can be taken orally, is easy to use, and can be a cosmetically acceptable therapy in selected cases of vitiligo. |
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Authors:
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A K Gupta; H F Haberman; D Pawlowski; G Shulman; I A Menon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 24 ISSN: 0011-9059 ISO Abbreviation: Int. J. Dermatol. Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1986-01-10 Completed Date: 1986-01-10 Revised Date: 2006-10-30 |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 528-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Canthaxanthin Carotenoids / adverse effects, analogs & derivatives*, pharmacology, therapeutic use Female Humans Male Mice Middle Aged Photosensitivity Disorders / therapy Skin Pigmentation / drug effects Vitiligo / therapy |
| Chemical | |
Reg. No./Substance:
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36-88-4/Carotenoids; 514-78-3/Canthaxanthin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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