Document Detail


Cantharidin: a comprehensive review of the clinical literature.
MedLine Citation:
PMID:  24945640     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal of warts, molluscum contagiosum (MC), calluses, and acquired perforating dermatoses. Objective: To provide a comprehensive literature review of the efficacy and safety of cantharidin in the management of various cutaneous conditions. Methods: A PubMed search was conducted using the term "cantharidin" combined with "warts", "plantar warts", "verruca vulgaris", "periungal", "subungual", "topical treatment", "topical therapy for warts", molluscum contagiosum", "perforating collagenosis," and "acantholysis." Results: A total of 749 articles were identified and 37 articles met inclusion criteria for this review. The majority of studies show that cantharidin is an effective and safe treatment for removal of warts and MC. Several studies also show potential novel applications of cantharidin in acquired perforating dermatosis, acute herpes zoster, and leishmaniasis. Adverse effects are generally mild but common and should be monitored, particularly in the pediatric population. Limitations: There is a paucity of high-powered clinical studies involving the use of cantharidin. Conclusion: Topical cantharidin is a safe and effective treatment for warts, molluscum contagiosum, and callus removal, with promising uses in perforating dermatoses and leishmaniasis.
Authors:
Richard Torbeck; Michael Pan; Elle DeMoll; Jacob Levitt
Publication Detail:
Type:  Journal Article     Date:  2014-06-15
Journal Detail:
Title:  Dermatology online journal     Volume:  20     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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