Document Detail

Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1.
MedLine Citation:
PMID:  23315998     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Notch2 appears to be the main determinant not only of biliary commitment of embryonic hepatoblasts during development but also of biliary reprogramming of adult hepatocytes. Notch2-dictated cell fates and morphogenesis in both embryonic hepatoblasts and adult hepatocytes rely on canonical Notch signaling but do not require Hes1. Adult liver cells possess a remarkable plasticity to assume new cell fates when embryonic signaling pathways are active. (HEPATOLOGY 2013).
Petia Jeliazkova; Simone Jörs; Marcel Lee; Ursula Zimber-Strobl; Jorge Ferrer; Roland M Schmid; Jens T Siveke; Fabian Geisler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-17
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-08-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2469-79     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Basic Helix-Loop-Helix Transcription Factors / metabolism
Hepatocytes / physiology
Homeodomain Proteins / metabolism
Immunoglobulin J Recombination Signal Sequence-Binding Protein / metabolism
Liver / embryology*,  metabolism*
Mice, Transgenic
Receptor, Notch2 / genetics,  metabolism*
Signal Transduction
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/Hes1 protein, mouse; 0/Homeodomain Proteins; 0/Immunoglobulin J Recombination Signal Sequence-Binding Protein; 0/Notch2 protein, mouse; 0/Receptor, Notch2
Comment In:
Hepatology. 2013 Nov;58(5):1857-9   [PMID:  23526421 ]
Hepatology. 2013 Nov;58(5):1859-60   [PMID:  23526407 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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