Document Detail


Canonical correlation analysis in the study of cerebral and peripheral haemodynamics interrelations with systemic variables in neonates supported on ECMO.
MedLine Citation:
PMID:  22879010     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonates supported on extracorporeal membrane oxygenation (ECMO) are at high risk of brain injury due to haemodynamic instability. In order to monitor cerebral and peripheral (muscle) haemodynamic and oxygenation changes in this population we used a dual-channel near-infrared spectroscopy (NIRS) system. In addition, to assess interrelations between NIRS and systemic variables, collected simultaneously, canonical correlation analysis (CCA) was employed. CCA can quantify the relationship between a set of variables and assess levels of dependency. In four out of five patients, systemic variables were found to be less inter-related with cerebral rather than peripheral NIRS measurements. Moreover, during ECMO flow manipulations, we found that the interrelation between the systemic and the NIRS cerebral/peripheral variables changed. The CCA method presented here can be used to assess differences between NIRS cerebral and NIRS peripheral responses due to systemic variations which may be indicative of physiological differences in the mechanisms that regulate oxygenation and/or haemodynamics of the brain and the muscle.
Authors:
Alexander Caicedo; Maria D Papademetriou; Clare E Elwell; Aparna Hoskote; Martin J Elliott; Sabine Van Huffel; Ilias Tachtsidis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  765     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-10     Completed Date:  2012-12-11     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / physiopathology*
Cerebrovascular Circulation*
Child, Preschool
Extracorporeal Circulation*
Extracorporeal Membrane Oxygenation / methods*
Hemodynamics
Humans
Infant
Infant, Newborn
Models, Statistical*
Monitoring, Physiologic*
Oxygen / metabolism*
Respiratory Insufficiency / prevention & control*
Spectroscopy, Near-Infrared
Grant Support
ID/Acronym/Agency:
G0701458//Medical Research Council
Chemical
Reg. No./Substance:
S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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