| Cannulation of the noncalcified aorta generates particles of microembolic nature: an experimental study using pig aorta. | |
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MedLine Citation:
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PMID: 18290885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM OF THE STUDY: Aortic cannulation during cardiac surgery is a potential etiological factor for perioperative stroke. Cannulae may dislodge aortic-wall calcifications. In addition, the sharp edge of the cannula-tip may shear off vessel-wall tissue, which can be expelled into the lumen. This hypothesis concerning source of emboli was tested in a noncalcified aortic perfusion model. METHODS: Pig aortas were pressurized and cannulated. Washout samples were collected before and after cannulation (n = 40). Particles were deposited onto a 10-microm filter and evaluated by microscopy and digital image analysis. RESULTS: A higher incidence of particles generated by cannulation was noted as compared to before the maneuver (p < 0.001). This increase included small (<0.1 mm, p < 0.001) and intermediate-size particles (0.1-0.5 mm, p < 0.001). Particles above 0.5 mm were few and were not associated with cannulation. CONCLUSIONS: Cannulation was a source of embolic material in the noncalcified aortic model. However, these particles were less than 0.5 mm in diameter and may contribute to neurocognitive decline after cardiac surgery. |
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Authors:
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Magnus Hedberg; Bertil Funck; Karl Gunnar Engström |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiac surgery Volume: 23 ISSN: 0886-0440 ISO Abbreviation: J Card Surg Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2008-02-22 Completed Date: 2008-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908809 Medline TA: J Card Surg Country: United States |
Other Details:
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Languages: eng Pagination: 39-43 Citation Subset: IM |
Affiliation:
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Department of Surgical and Perioperative Science, Heart Center, Cardiothoracic Division, Umeå University Hospital, Umeå, Sweden. magnus.hedberg@vll.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta* Catheterization / adverse effects* Disease Models, Animal Embolism / etiology* Stroke / prevention & control* Swine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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