Document Detail

Cannabis and psychosis: what is the link?
MedLine Citation:
PMID:  17703707     Owner:  NLM     Status:  MEDLINE    
Growing evidence supports the hypothesis that cannabis consumption is a risk factor for the development of psychotic symptoms. Nonetheless, controversy remains about the causal nature of the association. This review takes the debate further through a critical appraisal of the evidence. An electronic search was performed, allowing to identify 622 studies published until June 1st 2005. Longitudinal studies and literature reviews were selected if they addressed specifically the issues of the cannabis/psychosis relationship or possible mechanisms involved. Ten epidemiological studies were relevant: three supported a causal relationship between cannabis use and diagnosed psychosis; five suggested that chronic cannabis intake increases the frequency of psychotic symptoms, but not of diagnosed psychosis; and two showed no causal relationship. Potential neurobiological mechanisms were also identified, involving dopamine, endocannabinoids, and brain growth factors. Although there is evidence that cannabis use increases the risk of developing psychotic symptoms, the causal nature of this association remains unclear. Contributing factors include heavy consumption, length and early age of exposure, and psychotic vulnerability. This conclusion should be mitigated by uncertainty arising from cannabis use assessment, psychosis measurement, reverse causality and control of residual confounding.
Mohamed Ben Amar; Stéphane Potvin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of psychoactive drugs     Volume:  39     ISSN:  0279-1072     ISO Abbreviation:  J Psychoactive Drugs     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8113536     Medline TA:  J Psychoactive Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-42     Citation Subset:  IM    
Faculties of Continuing Education and Graduate Studies, University of Montreal, Quebec, Canada.
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MeSH Terms
Age Factors
Cannabis / chemistry*
Confounding Factors (Epidemiology)
Epidemiologic Studies
Marijuana Abuse / epidemiology
Marijuana Smoking / adverse effects*
Psychotic Disorders / epidemiology,  etiology*
Risk Factors
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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