Document Detail

Cannabinoids in eating disorders and obesity.
MedLine Citation:
PMID:  17952656     Owner:  NLM     Status:  MEDLINE    
Cannabinoid system is a crucial mechanism in regulating food intake and energy metabolism. It is involved in central and peripheral mechanisms regulating such behavior, interacting with many other signaling systems with a role in metabolic regulation. Cannabinoid agonists promote food intake, and soon a cannabinoid antagonist, rimonabant, will be marketed for the treatment of obesity. It not only causes weight loss, but also alleviates metabolic syndrome. We present a review of current knowledge on this subject, along with data from our own research: genetic studies on this system in eating disorders and obesity and studies locating cannabinoid receptors in areas related to food intake. Such studies suggest cannabinoid hyperactivity in obesity, and this excessive activity may have prognostic implications.
Francisco Arias Horcajadas
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-07-07
Journal Detail:
Title:  Molecular neurobiology     Volume:  36     ISSN:  0893-7648     ISO Abbreviation:  Mol. Neurobiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900963     Medline TA:  Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-28     Citation Subset:  IM    
Psychiatric Unit, Fundación Hospital Alcorcón, 28922 Alcorcón (Madrid), Spain.
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MeSH Terms
Appetite Regulation
Body Weight
Cannabinoids / agonists,  antagonists & inhibitors,  metabolism*
Eating Disorders / therapy*
Feeding Behavior
Obesity / therapy*
Reg. No./Substance:

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