| Cannabinoids, opioids and MDMA: neuropsychological interactions related to addiction. | |
| | |
MedLine Citation:
|
PMID: 20017726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine derivative with psychostimulant properties. This substance is widely used around the world by young adults in recreational settings. One of the most remarkable characteristic of ecstasy users is the concurrent consumption of several other drugs of abuse including psychostimulants, alcohol, tobacco, LSD, cannabis and opioids. This poly-drug pattern of use is now prompting research towards understanding how the combination of MDMA with cannabis and opioids could affect neuropsychobiological processes related to addiction. As with other drugs of abuse, behavioural evidence has been presented supporting the role of the endocannabinoid system as a modulator of the rewarding/reinforcing properties of MDMA. On the other hand, the neurochemical substrate for the complex interactions between the endocannabinoid system and MDMA is poorly understood. MDMA also modulates the activity of the dynorphinergic and enkephalinergic systems in several brain structures related to addiction, as it has been shown for other psychostimulants. The work regarding the contribution of micro- and delta-opioid receptors in the rewarding effects of MDMA shows differential results in pharmacological studies in rats, with respect to studies using knock-out mice. The present review describes the behavioural and neurochemical interactions between MDMA, cannabinoids and opioids with respect to addiction processes. |
| | |
Authors:
|
Patricia Robledo |
Related Documents
:
|
16376426 - Accumulation and elimination of cadmium in larval stage zebrafish following acute expos... 2341206 - Specific treatment demand as a definitory trait of a typology in heroin addicts: differ... 3627296 - The motivation to use drugs: a psychobiological analysis of urges. 11572966 - Deltafosb: a sustained molecular switch for addiction. 15585616 - Efficient elimination of b-lineage lymphomas by anti-cd20-auristatin conjugates. 10480256 - Immobilized biomembrane chromatography of highly lipophilic drugs. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Current drug targets Volume: 11 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-25 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 429-39 Citation Subset: IM |
Affiliation:
|
Laboratori de Neurofarmacologia, Departament de Ci?ncies Experimentals i de la Salut, Universitat Pompeu Fabra and Institut Municipal d'Investigaci? M?dica (IMIM), Barcelona, Spain. patricia.robledo@upf.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amphetamine-Related Disorders
/
etiology*,
metabolism,
psychology Animals Behavior, Addictive / etiology*, metabolism, psychology Brain / drug effects*, metabolism Central Nervous System Stimulants / adverse effects* Endocannabinoids / metabolism Humans Marijuana Abuse / etiology*, metabolism, psychology Mice Mice, Knockout Models, Animal N-Methyl-3,4-methylenedioxyamphetamine / adverse effects* Opioid Peptides / metabolism Opioid-Related Disorders / etiology*, metabolism, psychology Rats Receptors, Opioid / drug effects, metabolism Reinforcement (Psychology) Reward |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Stimulants; 0/Endocannabinoids; 0/Opioid Peptides; 0/Receptors, Opioid; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Telomere Maintenance as Therapeutic Target in Embryonal Tumours.
Next Document: Endogenous Cannabinoid and Opioid Systems and Their Role in Nicotine Addiction.