| Cannabinoid system in the skin - a possible target for future therapies in dermatology. | |
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MedLine Citation:
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PMID: 19664006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cannabinoids and their derivatives are group of more than 60 biologically active chemical agents, which have been used in natural medicine for centuries. The major agent of exogenous cannabinoids is Delta(9)-tetrahydrocannabinol (Delta(9)-THC), natural psychoactive ingredient of marijuana. However, psychoactive properties of these substances limited their use as approved medicines. Recent discoveries of endogenous cannabinoids (e.g. arachidonoylethanolamide, 2-arachidonoylglycerol or palmithyloethanolamide) and their receptors initiated discussion on the role of cannabinoid system in physiological conditions as well as in various diseases. Based on the current knowledge, it could be stated that cannabinoids are important mediators in the skin, however their role have not been well elucidated yet. In our review, we summarized the current knowledge about the significant role of the cannabinoid system in the cutaneous physiology and pathology, pointing out possible future therapeutic targets. |
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Authors:
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Piotr Kupczyk; Adam Reich; Jacek C Szepietowski |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Experimental dermatology Volume: 18 ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-11-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 669-79 Citation Subset: IM |
Affiliation:
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Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cannabinoids / metabolism*, therapeutic use Chemistry, Pharmaceutical / methods Dermatology / methods* Drug Design Endocannabinoids / metabolism, therapeutic use Humans Immune System Keratinocytes / cytology Models, Biological Models, Chemical Signal Transduction Skin / metabolism*, physiopathology Skin Diseases / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Cannabinoids; 0/Endocannabinoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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