| Cannabinoid system in the budgerigar brain. | |
| | |
MedLine Citation:
|
PMID: 16626655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cannabinoid receptor density and cannabinoid receptor-mediated G protein stimulation were studied by autoradiographic techniques throughout the budgerigar (Melopsittacus undulatus) brain. The maximal CB(1) receptor density value (using [(3)H]CP55,940 as radioligand) was found in the molecular layer of the cerebellum (Mol), and high binding values were observed in the nucleus taeniae amygdalae (TnA), nucleus preopticus medialis, and nucleus pretectalis. The highest net-stimulated [(35)S]GTPgammaS binding values induced by the selective CB(1) receptor agonist WIN55,212-2 were observed in the nucleus paramedianus internus thalami, and high values of [(35)S]GTPgammaS binding were observed in the TnA, Mol, arcopallium dorsale and arcopallium intermedium. The distribution data suggest that in the budgerigar, as previously indicated in mammals, cannabinoid receptors may be related to the control of several brain functions in the motor system, memory, visual system, and reproductive behavior. The discrepancies between the cannabinoid receptor densities and the cannabinoid receptor-mediated stimulation found in several budgerigar brain nuclei support the hypothesis, previously described for mammals, of the existence of different G(i/o) protein populations able to associate with the cannabinoid receptors, depending on the brain structure, and could reflect the relative importance that cannabinoid transmission could exerts in each cerebral area. |
| | |
Authors:
|
M E Alonso-Ferrero; M A Paniagua; R Mostany; F Pilar-Cuéllar; R Díez-Alarcia; A Pazos; A Fernández-López |
Related Documents
:
|
15901805 - The endocannabinoid noladin ether acts as a full agonist at human cb2 cannabinoid recep... 10939305 - Potential role of cannabinoids in parkinson's disease. 15837565 - Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in ... 23589615 - The nadph oxidase pathway is dysregulated by the p2x7 receptor in the sod1-g93a microgl... 20011135 - A receptor and binding protein interplay in the detection of a distinct pheromone compo... 10767545 - Gene conversion among chemokine receptors. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-04-13 |
Journal Detail:
|
Title: Brain research Volume: 1087 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-06-05 Completed Date: 2006-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 105-13 Citation Subset: IM |
Affiliation:
|
Dpto. Biología Celular, Facultad de Ciencias Biológicas y Ambientales, Universidad de León, Campus de Vegazana s/n, 24071, León, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autoradiography / methods Benzoxazines Brain / anatomy & histology, metabolism* Brain Mapping Calcium Channel Blockers / pharmacology Cyclohexanes / pharmacokinetics Cyclohexanols Guanosine 5'-O-(3-Thiotriphosphate) / pharmacokinetics Melopsittacus / anatomy & histology, metabolism* Morpholines / pharmacology Naphthalenes / pharmacology Phenols / pharmacokinetics Protein Binding / drug effects Radioligand Assay / methods Receptors, Cannabinoid / agonists, antagonists & inhibitors, metabolism* Sulfur Isotopes / pharmacokinetics Tritium / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
|
0/Benzoxazines; 0/Calcium Channel Blockers; 0/Cyclohexanes; 0/Cyclohexanols; 0/Morpholines; 0/Naphthalenes; 0/Phenols; 0/Receptors, Cannabinoid; 0/Sulfur Isotopes; 10028-17-8/Tritium; 134959-51-6/Win 55212-2; 37589-80-3/Guanosine 5'-O-(3-Thiotriphosphate); 83003-12-7/3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hair cell development: commitment through differentiation.
Next Document: AV3V lesions reduce the pressor response to L-glutamate into the RVLM.