Document Detail


Cannabinoid facilitation of behavioral and biochemical hedonic taste responses.
MedLine Citation:
PMID:  22063718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cannabinoid receptor agonists are known to stimulate feeding in humans and animals and this effect is thought to be related to an increase in food palatability. On the other hand, highly palatable food stimulates dopamine (DA) transmission in the shell of the nucleus accumbens (NAc) and this effect undergoes one trial habituation. In order to investigate the relationship between the affective properties of tastes and the response of NAc shell DA we studied the effect of delta-9-tetrahydrocannabinol (THC) on behavioral taste reactivity to intraoral infusion of appetitive (sucrose solutions) and aversive (quinine and saturated NaCl solutions) tastes and on the response of in vivo DA transmission in the NAc shell to intraoral sucrose. Rats were implanted with intraoral cannulae and the effect of systemic administration of THC on the behavioral reactions to intraoral infusion of sucrose and of quinine or saturated NaCl solutions were scored. THC increased the hedonic reactions to sucrose but did not affect the aversive reactions to quinine and NaCl. The effects of THC were completely blocked by the CB1 receptor inverse agonist/antagonist rimonabant given at doses that do not affect taste reactivity to sucrose. In rats implanted with microdialysis probes and with intraoral cannulae, THC, made sucrose effective in raising dialysate DA in the shell of the NAc. As in the case of highly palatable food (Fonzies, sweet chocolate), the stimulatory effect of sucrose on shell DA under THC underwent one trial habituation. Altogether, these findings demonstrate that stimulation of CB1 receptors specifically increases the palatability of hedonic taste without affecting that of aversive tastes. Consistent with the ability of THC to increase sucrose palatability is the observation that under THC pretreatment sucrose acquires the ability to induce a release of DA in the shell of the NAc and this property undergoes adaptation after repeated exposure to the taste (habituation). This article is part of a Special Issue entitled 'Central Control of Food Intake'.
Authors:
M A De Luca; M Solinas; Z Bimpisidis; S R Goldberg; G Di Chiara
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2011-11-02
Journal Detail:
Title:  Neuropharmacology     Volume:  63     ISSN:  1873-7064     ISO Abbreviation:  Neuropharmacology     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-10-23     Revised Date:  2013-07-17    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  161-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Toxicology, University of Cagliari, Italy. deluca@unica.it
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal / drug effects*
Cannabinoids / pharmacology*
Dopamine / metabolism
Dose-Response Relationship, Drug
Eating / drug effects
Food Preferences / drug effects
Male
Microdialysis
Nucleus Accumbens / drug effects
Pleasure / drug effects*
Rats
Rats, Sprague-Dawley
Sucrose / administration & dosage
Sweetening Agents / administration & dosage
Taste / drug effects*
Tetrahydrocannabinol / pharmacology*
Grant Support
ID/Acronym/Agency:
Z99 DA999999/DA/NIDA NIH HHS; ZIA DA000003-27/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Cannabinoids; 0/Sweetening Agents; 1972-08-3/Tetrahydrocannabinol; 57-50-1/Sucrose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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