Document Detail

Cannabinoid effects on behaviors maintained by ethanol or food: a within-subjects comparison.
MedLine Citation:
PMID:  16572003     Owner:  NLM     Status:  MEDLINE    
The cannabinoid CB1 antagonist rimonabant (SR141716A) has been proposed as a therapeutic agent for several addictive disorders, including alcoholism. Rimonabant may selectively reduce responding for an ethanol solution compared with an alternative. While this could represent a specific effect of CB1 inhibition on ethanol reinforcement, this could also result from differences in the baseline rates of behavior or experiences between comparison groups. We developed a procedure in rats that allows a within-subject comparison of ethanol and food-maintained responding and provides well matched baseline response rates. We determined the effects of acute doses of rimonabant (0.3-5.6 mg/kg, intraperitoneal) and the CB1 agonist Delta-9-tetrahydrocannabinol (1.0-5.6 mg/kg, intraperitoneal) on responding for food and ethanol under a multiple fixed-ratio schedule. To confirm that rimonabant blocked cannabinoid receptors, the ability of rimonabant to antagonize Delta-9-tetrahydrocannabinol effects in the same subjects under the same reinforcement schedule was also determined. In contrast with previous reports, rimonabant did not significantly alter responding for ethanol or food. The effects of Delta-9-tetrahydrocannabinol on responding for food were completely antagonized by rimonabant, whereas Delta-9-tetrahydrocannabinol effects on responding for ethanol were not. These results suggest that there may be neuroadaptation of the cannabinoid system following aging or chronic self-administration of ethanol.
Brett C Ginsburg; Richard J Lamb
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  17     ISSN:  0955-8810     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-30     Completed Date:  2006-10-19     Revised Date:  2009-07-07    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-57     Citation Subset:  IM    
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78228, USA.
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MeSH Terms
Behavior, Animal / drug effects*
Cannabinoids / pharmacology*
Central Nervous System Depressants / pharmacology*
Conditioning, Operant / drug effects*
Dose-Response Relationship, Drug
Drug Interactions
Ethanol / pharmacology*
Hallucinogens / pharmacology
Piperidines / pharmacology
Pyrazoles / pharmacology
Rats, Inbred Lew
Reinforcement (Psychology)
Tetrahydrocannabinol / pharmacology
Grant Support
Reg. No./Substance:
0/Cannabinoids; 0/Central Nervous System Depressants; 0/Hallucinogens; 0/Piperidines; 0/Pyrazoles; 158681-13-1/rimonabant; 1972-08-3/Tetrahydrocannabinol; 64-17-5/Ethanol

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