| Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury. | |
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MedLine Citation:
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PMID: 21788999 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of the fact that there is still no specific treatment for perinatal brain lesions due to the complexity of neonatal hypoxic-ischemic pathophysiology, the search of new neuroprotective therapies is of great interest. In this regard, therapeutic possibilities of the endocannabinoid system have grown lately. The endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury, acting as a natural neuroprotectant. Concerning perinatal asphyxia, the neuroprotective role of this endogenous system is emerging these years. The present review mainly focused on the current knowledge of the cannabinoids as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury. |
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Authors:
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Daniel Alonso-Alconada; Antonia Alvarez; Enrique Hilario |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience bulletin Volume: 27 ISSN: 1995-8218 ISO Abbreviation: Neurosci Bull Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256850 Medline TA: Neurosci Bull Country: China |
Other Details:
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Languages: eng Pagination: 275-85 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, Leioa 48940, Vizcaya, Spain; E-mail: enrique.hilario@ehu.es. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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