Document Detail

Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation.
MedLine Citation:
PMID:  17906675     Owner:  NLM     Status:  MEDLINE    
The emerging potential for the cannabinoid (CB) system in modulating gastrointestinal inflammation has gained momentum over the last few years. Traditional and anecdotal use of marijuana for gastrointestinal disorders, such as diarrhoea and abdominal cramps is recognized, but the therapeutic benefit of cannabinoids in the 21st century is overshadowed by the psychoactive problems associated with CB1 receptor activation. However, the presence and function of the CB2 receptor in the GI tract, whilst not yet well characterized, holds great promise due to its immunomodulatory roles in inflammatory systems and its lack of psychotropic effects. This review of our current knowledge of CB2 receptors in the gastrointestinal tract highlights its role in regulating abnormal motility, modulating intestinal inflammation and limiting visceral sensitivity and pain. CB2 receptors represent a braking system and a pathophysiological mechanism for the resolution of inflammation and many of its symptoms. CB2 receptor activation therefore represents a very promising therapeutic target in gastrointestinal inflammatory states where there is immune activation and motility dysfunction.
K L Wright; M Duncan; K A Sharkey
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-10-01
Journal Detail:
Title:  British journal of pharmacology     Volume:  153     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-04-02     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-70     Citation Subset:  IM    
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
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MeSH Terms
Cannabinoid Receptor Modulators / physiology
Gastrointestinal Tract / physiology*
Immune System / physiology
Inflammation / physiopathology*
Inflammatory Bowel Diseases / drug therapy,  physiopathology
Receptor, Cannabinoid, CB2 / physiology*
Respiratory Physiological Phenomena*
Reg. No./Substance:
0/Cannabinoid Receptor Modulators; 0/Receptor, Cannabinoid, CB2

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