Document Detail


Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats.
MedLine Citation:
PMID:  11218077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1-1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the cannabinoid receptor agonist WIN 55,212-2 is mediated by cannabinoid CB1 receptors.
Authors:
M P Germanò; V D'Angelo; M R Mondello; S Pergolizzi; F Capasso; R Capasso; A A Izzo; N Mascolo; R De Pasquale
Related Documents :
16408587 - Cannabinoids and dopamine receptors' action on calcium current in rat neurons.
23415097 - What ligand-gated ion channels can tell us about the allosteric regulation of g protein...
10220557 - Single amino acid substitution of serine82 to asparagine in first intracellular loop of...
24405637 - Vpac2 receptor agonist bay 55-9837 increases smn protein levels and moderates disease p...
2795467 - A dose-response analysis of intra-raphe tachykinin-induced hyperactivity.
23211707 - Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  363     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-19     Completed Date:  2001-05-03     Revised Date:  2009-09-04    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
Affiliation:
Pharmaco-Biological Department, School of Pharmacy, University of Messina, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Benzoxazines
Bornanes / pharmacology,  therapeutic use
Male
Morpholines / pharmacology,  therapeutic use*
Naphthalenes / pharmacology,  therapeutic use*
Piperidines / pharmacology,  therapeutic use
Pyrazoles / pharmacology,  therapeutic use
Rats
Rats, Wistar
Receptor, Cannabinoid, CB2*
Receptors, Cannabinoid
Receptors, Drug* / drug effects,  physiology
Stomach Ulcer / drug therapy*,  pathology
Stress, Physiological / pathology
Chemical
Reg. No./Substance:
0/Benzoxazines; 0/Bornanes; 0/Cnr2 protein, rat; 0/Morpholines; 0/Naphthalenes; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB2; 0/Receptors, Cannabinoid; 0/Receptors, Drug; 0/SR 144528; 134959-51-6/Win 55212-2; 158681-13-1/rimonabant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Aspirin, but not the more selective cyclooxygenase (COX)-2 inhibitors meloxicam and SC 58125, aggrav...
Next Document:  Linkage mapping in populations with karyotypic rearrangements.