Document Detail

Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats.
MedLine Citation:
PMID:  11218077     Owner:  NLM     Status:  MEDLINE    
The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1-1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the cannabinoid receptor agonist WIN 55,212-2 is mediated by cannabinoid CB1 receptors.
M P Germanò; V D'Angelo; M R Mondello; S Pergolizzi; F Capasso; R Capasso; A A Izzo; N Mascolo; R De Pasquale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  363     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-19     Completed Date:  2001-05-03     Revised Date:  2009-09-04    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
Pharmaco-Biological Department, School of Pharmacy, University of Messina, Italy.
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MeSH Terms
Bornanes / pharmacology,  therapeutic use
Morpholines / pharmacology,  therapeutic use*
Naphthalenes / pharmacology,  therapeutic use*
Piperidines / pharmacology,  therapeutic use
Pyrazoles / pharmacology,  therapeutic use
Rats, Wistar
Receptor, Cannabinoid, CB2*
Receptors, Cannabinoid
Receptors, Drug* / drug effects,  physiology
Stomach Ulcer / drug therapy*,  pathology
Stress, Physiological / pathology
Reg. No./Substance:
0/Benzoxazines; 0/Bornanes; 0/Cnr2 protein, rat; 0/Morpholines; 0/Naphthalenes; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB2; 0/Receptors, Cannabinoid; 0/Receptors, Drug; 0/SR 144528; 134959-51-6/Win 55212-2; 158681-13-1/rimonabant

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