Document Detail

Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior.
MedLine Citation:
PMID:  18004546     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Cannabinoid CB1 antagonists/inverse agonists suppress food-motivated behaviors and are being evaluated as potential appetite suppressants. It has been suggested that the effects of CB1 antagonism on food motivation could be related to actions on mesolimbic dopamine (DA). If this were true, then the effects of interference with cannabinoid CB1 transmission should closely resemble the effects of interference with DA transmission.
OBJECTIVE: To directly compare the effects of DA antagonists with those of CB1 antagonists/inverse agonists, the present studies employed a concurrent lever-pressing/chow-intake procedure. With this task, interference with DA transmission shifts choice behavior such that lever pressing for a preferred food is decreased but chow intake is increased.
RESULTS: Rats treated with IP injections of the DA D1 antagonist SCH39166 (ecopipam; 0.05-0.2 mg/kg) or the D2 antagonist eticlopride (0.025-0.1 mg/kg) showed substantial decreases in lever pressing and concomitant increases in chow consumption. In contrast, IP administration of the CB1 neutral antagonist AM4113 (4.0-16.0 mg/kg) or the CB1 antagonist/inverse agonist AM251 (2.0-8.0 mg/kg) decreased operant responding for pellets, but there was no corresponding increase in chow intake.
CONCLUSIONS: These effects of CB1 antagonists/inverse agonists were similar to those produced by the appetite suppressant fenfluramine and by prefeeding. In contrast, low doses of DA antagonists leave primary food motivation intact, but shift behaviors toward food reinforcers that can be obtained with lower response costs. These results suggest that the effects of interference with CB1 transmission are readily distinguishable from those of reduced DA transmission.
K S Sink; V K Vemuri; T Olszewska; A Makriyannis; J D Salamone
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2007-11-15
Journal Detail:
Title:  Psychopharmacology     Volume:  196     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-08-14     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  565-74     Citation Subset:  IM    
Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA.
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MeSH Terms
Benzazepines / administration & dosage,  pharmacology
Choice Behavior / drug effects*
Conditioning, Operant / drug effects*
Dopamine Antagonists / administration & dosage,  pharmacology*
Feeding Behavior / drug effects*
Food Preferences
Injections, Intraperitoneal
Piperidines / administration & dosage,  pharmacology
Pyrazoles / administration & dosage,  pharmacology
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1 / agonists,  antagonists & inhibitors*
Reinforcement Schedule
Salicylamides / administration & dosage,  pharmacology
Grant Support
Reg. No./Substance:
0/AM 251; 0/AM4113; 0/Benzazepines; 0/Dopamine Antagonists; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 0/Salicylamides; 0X748O646K/ecopipam; J8M468HBH4/eticlopride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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