Document Detail

Canine small bowel motor activity in response to intraduodenal infusion of nutrient mixtures of increasing caloric load in dogs.
MedLine Citation:
PMID:  12924640     Owner:  NLM     Status:  MEDLINE    
The effect of nutrients on small intestinal motility is controversial. Our aim was to analyze the effect of intraduodenal infusion of mixtures of nutrients of increasing caloric load, on intestinal motility. Studies were performed in dogs with a duodenal cannula. Isosmolar infusions of saline, 0.5, 2, and 4 kcal/min were performed and motility recorded by means of infused catheters. Nonstatistically significant differences were observed between frequency of contractions during infusion of 0.5 (4.1 +/- 1.6 cpm) and 2 kcal/min (5.3 +/- 1.5 cpm) compared to control (4.3 +/- 1.9 cpm). With 4 kcal/min a significant decrease of frequency (2.7 +/- 0.9 cpm) was observed. A similar finding was observed for amplitude of contrations. With 0.5 kcal/min fasting cyclic activity was still present, but the numbers of phase III were significantly reduced, associated with an increased duration of phase II. With higher caloric loads cyclic fasting activity was replaced by marked variations of frequency, following a cyclic pattern. A lower threshold for mechanisms switching the fasting to fed state was observed, compared to those controlling frequency and amplitude.
Carlos Defilippi
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  48     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-19     Completed Date:  2003-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1482-6     Citation Subset:  AIM; IM    
Program of Physiology and Biophysics, School of Medicine, University of Chile, Santiago, Chile.
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MeSH Terms
Energy Intake / physiology*
Enteral Nutrition
Fasting / physiology
Gastrointestinal Motility / physiology*
Gastrointestinal Transit / physiology
Intestine, Small / physiology*
Myoelectric Complex, Migrating / physiology
Postprandial Period / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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