| Canine serum thermostable alkaline phosphatase isoenzyme from a dog with hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 17085898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A dog histopathologically diagnosed with hepatocellular carcinoma (HCC) showed very high serum alkaline phosphatase (ALP) activity. A supernatant of ascitic fluid and tumor tissue extracted from the dog also showed much higher ALP activity than normal. ALP isoenzyme analysis of samples was performed using polyacrylamide gel disk electrophoresis, and a wide, broad abnormal band was observed. By various treatments, the abnormal band showed thermostability, which is a characteristic of tumor-associated ALP that has only been reported in humans. The thermostable ALP isoenzyme was not found in sera from 39 dogs with several types of tumor that originated from the liver, except for HCC, nor was it found in 10 dogs with hepatic diseases that did not include hepatic tumors. The thermostable ALP isoenzyme seemed to be associated with canine HCC. |
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Authors:
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Yu-ichi Fukui; Jun Sato; Reeko Sato; Jun Yasuda; Yoshihisa Naito |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 68 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-11-06 Completed Date: 2006-12-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1129-32 Citation Subset: IM |
Affiliation:
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Department of Veterinary Medicine, Faculty of Agriculture, Iwate University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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blood* Animals Carcinoma, Hepatocellular / enzymology*, pathology, veterinary* Dog Diseases / enzymology*, pathology Dogs Electrophoresis, Polyacrylamide Gel / veterinary Enzyme Stability Fatal Outcome Female Hot Temperature Isoenzymes / blood Liver Neoplasms / enzymology*, pathology, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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