Document Detail

Canine pulmonary hypertension model induced by pulmonary artery embolization of gelatin sponges.
MedLine Citation:
PMID:  8560089     Owner:  NLM     Status:  MEDLINE    
We attempted to develop a pulmonary hypertension model in dogs by gelatin sponge embolization. We then monitored right-ventricular pressure overload by echocardiography. Gelatin sponges (Spongel, Yamanouchi, Tokyo) were homogenized and mixed in normal saline (0.6 mg/ml). The mixture was administered via the jugular vein to general pulmonary emboli. Repeated administration of the sponges increased the mean pulmonary arterial pressure and caused right ventricular pressure overload. The degree of pulmonary hypertension was proportional to the volume of gelatin sponge injected. Echocardiography, performed both before and after embolization, proved useful assessing for the degree of right-ventricular pressure overload.
S Yamamoto; K Kawahara; T Takahashi; T Tagawa; A Nakamura; M Muraoka; M Tomita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  62     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-23     Completed Date:  1996-02-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  IM    
First Department of Surgery, Nagasaki University School of Medicine, Japan.
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MeSH Terms
Disease Models, Animal*
Hypertension, Pulmonary / etiology*,  physiopathology
Pulmonary Embolism / etiology*
Pulmonary Wedge Pressure
Reg. No./Substance:

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