| Canine model of chronic pancreatitis due to chronic ischemia. | |
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MedLine Citation:
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PMID: 7514552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An experimental model of chronic pancreatitis was produced by a chronic ischemia which was induced by ligation and separation of branches flowing into the left pancreatic lobe from the splenic artery. Macroscopic findings at 3 and 6 months after model preparation showed that the pancreas was hard, with severe inflammatory change. In the secretin-cerulein test at 3 and 6 months, the flow rate of pancreatic juice, amylase output and bicarbonate concentration were significantly reduced as compared with the controls. The histopathological findings consisted of a decrease in the pancreatic parenchyma, replacement of fat, severe inflammatory cell infiltration, extensive fibrosis and tubular complexes. As this model closely resembles human chronic pancreatitis, we conclude that ischemia is an etiological factor in chronic pancreatitis. |
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Authors:
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T Tanaka; Y Ichiba; Y Miura; H Ito; K Dohi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestion Volume: 55 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 1994 |
Date Detail:
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Created Date: 1994-06-17 Completed Date: 1994-06-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 86-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, Hiroshima University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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secretion Animals Bicarbonates / metabolism Chronic Disease Disease Models, Animal Dogs Fibrosis Ischemia / complications* Ligation Pancreas / blood supply*, metabolism, pathology Pancreatic Juice / secretion Pancreatitis / etiology*, metabolism, pathology Splenic Artery |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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