Document Detail

Canine left ventricular volume response to mechanical ventilation with PEEP.
MedLine Citation:
PMID:  7013569     Owner:  NLM     Status:  MEDLINE    
To determine the cause of decreased cardiac output (CO) resulting from the use of PEEP, hemodynamic and pulmonary parameters and radiographic estimates of left ventricular volumes were observed in nine dogs under three conditions: control, PEEP (15 cm H2O), and PEEP with intravascular (IV) volume expansion. Volume expansion was sufficient to return the CO to control values. Cardiac index (CI), stroke volume index (SI), left ventricular stroke work index (LVSWI) all decreased approximately 30 per cent with the application of PEEP. Ejection fraction remained unchanged. With IV volume expansion, the CI, SI, left ventricular end-diastolic volume index, and LVSWI returned to approximate control values. The transmural left ventricular end-diastolic pressure (TMLVEDP) did not change significantly. The authors therefore conclude that reduced left ventricular preload is the cause of decreased cardiac output by PEEP and that indirect evidence of preload (transmural left ventricular end-diastolic pressure) is not an adequate assessment of the force-length relationship under the conditions stated.
D R Brown; M G Bazaral; P H Nath; D J Delaney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  54     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-12     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiac Output*
Cardiac Volume*
Forced Expiratory Volume
Heart Ventricles
Intermittent Positive-Pressure Ventilation
Respiration, Artificial*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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