| Canine interdigestive and postprandial gallbladder motility and emptying. | |
| | |
MedLine Citation:
|
PMID: 6720894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objectives of this study were to characterize intraluminal gallbladder pressure during fasting and postprandially and to determine the relationships between its intraluminal pressure and emptying. Conscious dogs, with chronic indwelling gallbladder and duodenal catheters to measure pressures and infuse nonabsorbable markers, were used to quantify intraluminal pressures and emptying of gallbladder contents and bile into the duodenum during interdigestive and postprandial periods. During the interdigestive period, a brief rise in intragallbladder pressure followed by the flow of bile and 20% of gallbladder marker into the duodenum occurred only during phase II (a period of irregular duodenal contractility preceded by absent duodenal activity, phase I, and followed by a period of regular duodenal contractility, phase III). We suggest that intragallbladder pressure increased secondary to contraction of the gallbladder against a closed sphincter of Oddi and its decline to base line was accompanied by sphincter relaxation, partial gallbladder emptying, and flow of bile into the duodenum. Postprandially, intragallbladder pressure transiently increased and was followed by an isotonic phase lasting 74 +/- 12 min that ended with the onset of rhythmic large-amplitude pressure elevations that continued for 5.1 +/- 1.6 h. Gallbladder emptying was most rapid during the first 30 min postprandially and was completed by 2 h. Thereafter, large-amplitude gallbladder pressure elevations may prevent gallbladder filling and divert hepatic bile into the duodenum until return of the fasting pattern. |
| | |
Authors:
|
O J Traynor; R R Dozois; E P DiMagno |
Related Documents
:
|
16078624 - Assessment of the esophageal pressure in gastroesophageal reflux disease by the local r... 1007834 - The effect of pressure changes inside the antrum on lower esophageal sphincter (les) pr... 8026254 - Response of gastric fundus to rectal distension in healthy persons. 14668594 - Impact of two different types of anal retractor on fecal continence after fistula repai... 10417864 - Effect of amlodipine on blood pressure responses in local and whole-body cooling in nor... 2618634 - The immediate pressure response to primary laser trabeculoplasty--a comparison of one- ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of physiology Volume: 246 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Apr |
Date Detail:
|
Created Date: 1984-05-30 Completed Date: 1984-05-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G426-32 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile / secretion* Dogs Duodenum / physiology* Eating Female Gallbladder / physiology* Hydrostatic Pressure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induction of rat hepatic and intestinal alkaline phosphatase activity produced by bile from bile duc...
Next Document: Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morpholog...