Document Detail

Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum.
MedLine Citation:
PMID:  23331699     Owner:  NLM     Status:  In-Data-Review    
Background -  Cutaneous T-cell lymphoma (CTCL) in dogs is a heterogeneous disease complex, which consists of nonepitheliotropic (NE) and epitheliotropic forms. These lymphomas are readily recognized by the presence of dominant populations of cytologically atypical lymphocytes. Objective -  The objective of this study was to introduce the key features of inflamed NE-CTCL, which is easily confused with reactive, inflammatory histiocytic disease. Animals -  Twenty-four dogs (mean age 7.5 years) presented with inflamed NE-CTCL. Lesions presented as nodules, plaques or masses. An initial diagnosis of cutaneous reactive histiocytosis (11 dogs) or histiocytic neoplasia (three dogs) was made by primary pathologists. Methods -  Lesions were assessed by histology and immunohistochemistry to detect canine leukocyte antigens. Lesional genomic DNA was extracted and gene rearrangement analysis of the T-cell receptor γ locus was assessed. Results -  The cutaneous lesions consisted of pleocellular infiltration of the dermis with variable extension into the subcutis. The lesions often surrounded vessels and adnexae. Epitheliotropism was minimal or lacking. Small lymphocytes, plasma cells and intermediate to large, cytologically atypical lymphocytes were scattered between prominent histiocytic infiltrates. Atypical lymphocytes often had marked variation in the intensity of CD3 expression. Molecular clonality analysis of the T-cell receptor γ locus revealed clonal expansion of T cells in 22 of 23 dogs tested. Conclusion -  The recognition of inflamed NE-CTCL and its differentiation from cutaneous reactive histiocytosis depends on careful assessment of lymphocyte morphology and immunostaining patterns. Confirmation of the diagnosis is best accomplished by T-cell antigen receptor gene rearrangement analysis.
Peter F Moore; Verena K Affolter; Stefan M Keller
Related Documents :
2194259 - Benign pulmonary lesions that may be misdiagnosed as malignant.
24426349 - Primary granulocytic sarcoma of meninges and mediastinum as diagnostic dilemma.
18620999 - Angiomyolipoma of the anterior mediastinum.
24448119 - Pruritic porokeratotic peno-scrotal plaques: porokeratosis or porokeratotic epidermal r...
25123949 - Role of braf molecular analysis in the management of papillary thyroid carcinoma: analy...
20573459 - Primary cutaneous blastic plasmacytoid dendritic cell neoplasm without extracutaneous m...
9523639 - Cutaneous mycoses in chameleons caused by the chrysosporium anamorph of nannizziopsis v...
9494499 - Sonographic comparison of intraarterial co2 and helium microbubbles for detection of he...
8510249 - Covered exstrophy with sequestered colonic remnant.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary dermatology     Volume:  24     ISSN:  1365-3164     ISO Abbreviation:  Vet. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426187     Medline TA:  Vet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  204-e45     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Veterinary Dermatology © 2013 ESVD and ACVD.
Department of Pathology, Microbiology and Immunology, University of California, Davis, CA 95616, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Epithelial-to-mesenchymal transition: immunohistochemical investigation of related molecules in cani...
Next Document:  Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and ...