Document Detail


Candidemia outcomes not improved with statin use.
MedLine Citation:
PMID:  22662759     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Candidemia is an important cause of morbidity and mortality. As statins interfere with yeast membrane synthesis, we assessed whether use of statins during candidemia may cause differences in clinical outcomes. A retrospective review of 124 candidemia episodes during 2003-2008 in which all-cause and attributable mortality, length of stay and level of care were compared for patients who received and those who did not receive statins. A total of 124 candidemia events were observed involving 14 patients on statins and 110 without statins. Overall mortality in candidemia cases was 46%, but only 2% was attributed to candidemia. No differences were observed in clinical outcomes for the two groups of patients. During the last 2-year period of our study, there were higher rates of candidemia caused by non-C. albicans Candida spp., particularly those due to C. glabrata and C. parapsilosis. In conclusion, statin use during candidemia did not alter mortality, length of stay, or intensive care requirement of our patients, despite higher rates of non-C. albicans Candida species isolated during the last 2 years of our study.
Authors:
Meredith L Welch; Angelike P Liappis; Virginia L Kan
Related Documents :
423329 - Pubectomy for repair of membranous urethral strictures.
11180779 - Ureteroneocystostomy with and without the use of an intravesical catheter.
19787379 - Efficacy of multifaceted interventions in reducing complications of peripherally insert...
20301819 - Ultrasound-guided continuous femoral nerve block for analgesia after total knee arthrop...
20230479 - Cryoablation with an 8-mm tip catheter for pediatric atrioventricular nodal reentrant t...
3481469 - Development of nosocomial and iatrogenic urinary tract infections (uti) following urolo...
20650829 - Relationship of internal jugular venous oxygen saturation and perfusion flow rate in ch...
9050699 - Is estrogen necessary after hysteroscopic incision of the uterine septum?
1451819 - Adverse outcome in surgery for chronic leg ischaemia--risk factors and risk prediction ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-4
Journal Detail:
Title:  Medical mycology : official publication of the International Society for Human and Animal Mycology     Volume:  -     ISSN:  1460-2709     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Infectious Diseases Section, VA Medical Center and George Washington University , Washington, DC , USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Human genetic susceptibility to Candida infections.
Next Document:  The possible mechanism of rhapontigenin influencing antifungal activity on Candida albicans.