Document Detail


Candidemia in immunocompromised patients.
MedLine Citation:
PMID:  1562683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study reviews data on patients with fungemia and confirms the high prevalence (50%) of infections caused by non-albicans species of Candida. Fungemia due to C. albicans or Torulopsis glabrata occurred significantly more often in patients with a solid tumor, while fungemia due to Candida tropicalis or Candida krusei was significantly more common in patients with hematologic malignancy (P = .001). For 31% of patients, only a single blood culture was positive for yeasts, and the prognosis for these patients was not significantly different than that for patients with three or more positive blood cultures (P = 1), including those who had C. albicans fungemia. The overall mortality rate was 41.8%, which is much lower than that previously reported in studies of patients with cancer. No significant difference was observed between patients treated with amphotericin B and those treated with fluconazole in this retrospective analysis. Although no significant difference was observed in the mortality rate among patients who had fungemia with or without neutropenia, the incidence of disseminated candidiasis was significantly higher among neutropenic patients (P = .03).
Authors:
F Meunier; M Aoun; N Bitar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  14 Suppl 1     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-19     Completed Date:  1992-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S120-5     Citation Subset:  IM    
Affiliation:
Service de Médecine Interne et Laboratoire d'Investigation Clinique Henri Tagnon, Centre des Tumeurs de l'Université Libre de Bruxelles, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Candidiasis / epidemiology,  etiology*,  mortality
Female
Fungemia / epidemiology,  etiology*,  mortality
Humans
Immunocompromised Host*
Incidence
Male
Middle Aged
Neoplasms / complications*
Neutropenia / complications*
Prevalence
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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