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Candidate Gene Association Study of BMI-Related Loci, Weight, and Adiposity in Old Age.
MedLine Citation:
PMID:  23160366     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Most genome-wide association studies are confined to middle-aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)-associated SNPs to weight, BMI, % fat, visceral and subcutaneous adipose tissue in Health ABC and AGES-Reykjavik comprising 4,846 individuals of European Ancestry, and 1,139 African Americans over age 65. SNPs were scaled using effect estimates from candidate SNPs. In Health ABC, a SNP near GNPDA2 was modestly associated with weight and SAT area (p = .008, p = .001). Risk score (sum of scaled SNPs) was associated with weight, BMI, and SAT area (p < .0001 for all), but neither GNPDA2 nor risk score was associated with weight, BMI, visceral adippose tissue, subcutaneous adipose tissue, or % fat in AGES-Reykjavik. In African Americans, a SNP near SEC16B was weakly associated with weight (p = .04). In this sample of older adults, no BMI-associated SNPs were associated with weight or adiposity.
Authors:
Rachel A Murphy; Michael A Nalls; Margaux Keller; Melissa Garcia; Stephen B Kritchevsky; Frances A Tylavsky; Anne B Newman; Gregory J Tranah; Gudny Eiriksdottir; Vilmundur Gudnason; Tamara B Harris
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-16
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  -     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
National Institute on Aging, 7201 Wisconsin Ave, Gateway Building 3C-309, Bethesda, MD 20892. Rachel.murphy@nih.gov.
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