|Candidate gene association study of BMI-related loci, weight, and adiposity in old age.|
|PMID: 23160366 Owner: NLM Status: MEDLINE|
|Most genome-wide association studies are confined to middle-aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)-associated SNPs to weight, BMI, % fat, visceral and subcutaneous adipose tissue in Health ABC and AGES-Reykjavik comprising 4,846 individuals of European Ancestry, and 1,139 African Americans over age 65. SNPs were scaled using effect estimates from candidate SNPs. In Health ABC, a SNP near GNPDA2 was modestly associated with weight and SAT area (p = .008, p = .001). Risk score (sum of scaled SNPs) was associated with weight, BMI, and SAT area (p < .0001 for all), but neither GNPDA2 nor risk score was associated with weight, BMI, visceral adippose tissue, subcutaneous adipose tissue, or % fat in AGES-Reykjavik. In African Americans, a SNP near SEC16B was weakly associated with weight (p = .04). In this sample of older adults, no BMI-associated SNPs were associated with weight or adiposity.|
|Rachel A Murphy; Michael A Nalls; Margaux Keller; Melissa Garcia; Stephen B Kritchevsky; Frances A Tylavsky; Anne B Newman; Gregory J Tranah; Gudny Eiriksdottir; Vilmundur Gudnason; Tamara B Harris|
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|Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2012-11-16|
|Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 68 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2013 Jun|
|Created Date: 2013-05-22 Completed Date: 2013-08-15 Revised Date: 2014-06-03|
Medline Journal Info:
|Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States|
|Languages: eng Pagination: 661-6 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
African Americans / ethnology, genetics*
Aged, 80 and over
Body Mass Index*
European Continental Ancestry Group / ethnology, genetics*
Gene Expression Regulation
Genetic Predisposition to Disease
Obesity / epidemiology, genetics*
Overweight / genetics
Polymorphism, Single Nucleotide*
United States / epidemiology
|HHSN268200782096C//PHS HHS; N01-AG-1-2100/AG/NIA NIH HHS; N01-AG-6-2101/AG/NIA NIH HHS; N01-AG-6-2103/AG/NIA NIH HHS; N01-AG-6-2106/AG/NIA NIH HHS; R01AG032098-01A1/AG/NIA NIH HHS; Z01 AG000932-04/AG/NIA NIH HHS|
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