Document Detail


Candidate gene association study of BMI-related loci, weight, and adiposity in old age.
MedLine Citation:
PMID:  23160366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most genome-wide association studies are confined to middle-aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)-associated SNPs to weight, BMI, % fat, visceral and subcutaneous adipose tissue in Health ABC and AGES-Reykjavik comprising 4,846 individuals of European Ancestry, and 1,139 African Americans over age 65. SNPs were scaled using effect estimates from candidate SNPs. In Health ABC, a SNP near GNPDA2 was modestly associated with weight and SAT area (p = .008, p = .001). Risk score (sum of scaled SNPs) was associated with weight, BMI, and SAT area (p < .0001 for all), but neither GNPDA2 nor risk score was associated with weight, BMI, visceral adippose tissue, subcutaneous adipose tissue, or % fat in AGES-Reykjavik. In African Americans, a SNP near SEC16B was weakly associated with weight (p = .04). In this sample of older adults, no BMI-associated SNPs were associated with weight or adiposity.
Authors:
Rachel A Murphy; Michael A Nalls; Margaux Keller; Melissa Garcia; Stephen B Kritchevsky; Frances A Tylavsky; Anne B Newman; Gregory J Tranah; Gudny Eiriksdottir; Vilmundur Gudnason; Tamara B Harris
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-11-16
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  68     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-22     Completed Date:  2013-08-15     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  661-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adiposity / genetics*
African Americans / ethnology,  genetics*
Aged
Aged, 80 and over
Aging*
Body Mass Index*
Body Weight
European Continental Ancestry Group / ethnology,  genetics*
Female
Gene Expression Regulation
Genetic Loci*
Genetic Predisposition to Disease
Genetic Testing
Genome, Human
Humans
Male
Obesity / epidemiology,  genetics*
Overweight / genetics
Phenotype
Polymorphism, Single Nucleotide*
Prospective Studies
Sampling Studies
United States / epidemiology
Grant Support
ID/Acronym/Agency:
HHSN268200782096C//PHS HHS; N01-AG-1-2100/AG/NIA NIH HHS; N01-AG-6-2101/AG/NIA NIH HHS; N01-AG-6-2103/AG/NIA NIH HHS; N01-AG-6-2106/AG/NIA NIH HHS; R01AG032098-01A1/AG/NIA NIH HHS; Z01 AG000932-04/AG/NIA NIH HHS
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