Document Detail

Candidal versus bacterial late-onset sepsis in very low birthweight infants in Israel: a national survey.
MedLine Citation:
PMID:  17275963     Owner:  NLM     Status:  MEDLINE    
Candidal infections are one of the common causes of late-onset sepsis (LOS) among very low birthweight (VLBW) infants, and are associated with substantial morbidity and mortality. The aim of this study was to evaluate the perinatal and neonatal risk factors for fungal LOS compared with bacterial LOS in VLBW infants. This was a population-based observational study of VLBW infants in 28 neonatal intensive care units across Israel, with information on 11,830 infants born between 1995 and 2002 from the Israeli National VLBW infant database. The study population comprised 3054 infants with one or more episodes of LOS. Univariate analysis and logistic regression models were used to compare perinatal and neonatal risk factors between infants with fungal sepsis only (N=179) and those with bacterial sepsis only (N=2630). The mean birthweight and gestational age of infants with candidal LOS were significantly lower (940 g; 27.1 weeks) than those in the bacterial LOS group (1027 g; 28.3 weeks) (P<0.001). Logistic regression analysis showed that candidal sepsis, in contrast to bacterial sepsis, was independently associated with decreasing gestational age and bronchopulmonary dysplasia (BPD). In addition, BPD only [odds ratio (OR) 1.84; 95% confidence intervals (CI) 1.03-3.23] and BPD with postnatal steroid therapy (OR 2.66; 95% CI 1.59-4.46) were independently associated with an increased risk for candidal sepsis.
Imad R Makhoul; Yoram Bental; Meir Weisbrod; Polo Sujov; Ayala Lusky; Brian Reichman;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-02
Journal Detail:
Title:  The Journal of hospital infection     Volume:  65     ISSN:  0195-6701     ISO Abbreviation:  J. Hosp. Infect.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007166     Medline TA:  J Hosp Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  IM    
Department of Neonatology, Meyer Children's Hospital-Rambam Medical Center, Haifa, Israel.
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MeSH Terms
Bacterial Infections / epidemiology*,  etiology
Bronchopulmonary Dysplasia / complications,  microbiology*
Candidiasis / epidemiology*,  etiology
Gestational Age
Infant, Newborn
Infant, Very Low Birth Weight*
Israel / epidemiology
Odds Ratio
Risk Factors
Sepsis / epidemiology,  etiology,  microbiology*
Steroids / therapeutic use*
Reg. No./Substance:

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