Document Detail


Candida parapsilosis peritonitis has more complications than other Candida peritonitis in peritoneal dialysis patients.
MedLine Citation:
PMID:  16703797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Candida parapsilosis is the most prevalent pathogen of fungal peritonitis in peritoneal dialysis (PD). The difference between C. parapsilosis peritonitis and other C. species for clinical outcomes and treatment responses to fungal peritonitis remains unclear. This retrospective study of fungal peritonitis attempts to answer that question. A total 22 patients with fungal peritonitis in 762 PD patients were enrolled in this study. The mean age of the 22 patients, 9 males and 13 females, was 54.7 +/- 12.5 years with a mean PD duration of 39.7 +/- 33.4 months. Candida species accounted for 86% (19 cases) of fungal peritonitis and 41% (9 cases) were C. parapsilosis. Thirteen (59%) patients received fluconazole as monotherapy; others received either amphotericin B alone or in combination with fluconazole. Catheters were removed for all patients. The mean duration from peritonitis onset to catheter removal was 5.8 +/- 4.1 days. Eleven (50%) patients developed severe complications, with abscess formation or persistent peritonitis after catheter removal. C. parapsilosis peritonitis had a higher complication rate than other Candida species (78% versus 20%, p = 0.012). In patients who received fluconazole as monotherapy, the rate of severe complications of C. parapsilosis peritonitis was statistically higher than those of other Candida species (100% versus 29%, p = 0.013). Because of different severity and prognosis, C. parapsilosis peritonitis in PD patients should be treated more aggressively than other Candida species.
Authors:
Kuan-Hsing Chen; Chiz-Tsung Chang; Chun-Chen Yu; Jeng-Yi Huang; Chih-Wei Yang; Cheng-Chieh Hung
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  28     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-17     Completed Date:  2006-11-30     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-6     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Candidiasis / complications*
Female
Humans
Male
Middle Aged
Peritoneal Dialysis*
Peritonitis / complications*,  microbiology*
Retrospective Studies

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