Document Detail


Candida parapsilosis and the neonate: epidemiology, virulence and host defense in a unique patient setting.
MedLine Citation:
PMID:  23030332     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Invasive candidiasis is a common problem in premature infants that leads to high morbidity and mortality. Although Candida albicans has historically been the most prominent species involved in these infections and has therefore been the subject of the most study, Candida parapsilosis is increasing in frequency, and neonates are disproportionately affected. This article reviews unique aspects of the epidemiology of this organism as well as strategies for prophylaxis against invasive candidiasis in general. Additionally, important differences between C. parapsilosis and C. albicans are coming to light related to virulence determinants and interactions with components of host immunity. These developments are reviewed while highlighting the significant gaps in our understanding that remain to be elucidated.
Authors:
Brian D W Chow; Jennifer R Linden; Joseph M Bliss
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Expert review of anti-infective therapy     Volume:  10     ISSN:  1744-8336     ISO Abbreviation:  Expert Rev Anti Infect Ther     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-03     Completed Date:  2013-02-13     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101181284     Medline TA:  Expert Rev Anti Infect Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  935-46     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hasbro Children's Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / therapeutic use
Biofilms
Candida / immunology,  pathogenicity*,  physiology
Candidiasis / drug therapy,  epidemiology*,  immunology*,  microbiology
Cell Adhesion
Drug Resistance, Fungal
Host-Pathogen Interactions
Humans
Infant, Newborn
Infant, Newborn, Diseases / epidemiology*,  immunology,  microbiology
Prevalence
Receptors, Pattern Recognition / immunology
Risk Factors
Virulence Factors
Grant Support
ID/Acronym/Agency:
5P20RR018728-10/RR/NCRR NIH HHS; 8P20GM103537-10/GM/NIGMS NIH HHS; P20 GM103537/GM/NIGMS NIH HHS; P20 RR018728/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Receptors, Pattern Recognition; 0/Virulence Factors
Comments/Corrections

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