Document Detail

Candida parapsilosis endocarditis: a comparative review of the literature.
MedLine Citation:
PMID:  17805589     Owner:  NLM     Status:  MEDLINE    
Fungal endocarditis (FE) is an uncommon disease, and while accounting for only 1.3-6% of all cases of infectious endocarditis, it carries a high mortality risk. Although Candida albicans represents the main etiology of FE, C. parapsilosis is the most common non-albicans species. We report the case of a 32-year-old man with a history of prior intravenous drug (IVD) use hospitalized with endocarditis due to C. parapsilosis and review all 71 additional cases documented in the literature. A retrospective analysis of the 72 C. parapsilosis cases compared to 52 recently reviewed cases of C. albicans endocarditis was conducted to identify organism-specific clinical peculiarities. The most common predisposing factor for C. parapsilosis endocarditis (41/72; 57.4%) involved prosthetic valves followed by IVD use (12/72; 20%). Peripheral embolic and/or hemorrhagic events occurred in 28/64 (43.8%) patients, mostly in cerebral and lower limb territories. Overall mortality was 41.7%. Combined surgical and clinical treatment was associated with a lower mortality. Few patients received the newer antifungal agents, and it would appear that more experience is required for their use in the treatment of C. parapsilosis endocarditis.
C Garzoni; V A Nobre; J Garbino
Related Documents :
20495509 - Nontoxinogenic corynebacterium diphtheriae as a rare cause of native endocarditis in ch...
11147029 - Aspergillus endocarditis in a lung transplant recipient. a case report and review of th...
20684779 - Tropheryma whipplei tricuspid endocarditis: a case report and review of the literature.
2599549 - Tricuspid valve replacement for gross tricuspid insufficiency due to dysplastic valve--...
3759799 - Pathological anatomy of ventricular septal defect associated with aortic valve prolapse...
8834719 - Management of mitral valve stenosis in pregnancy: case presentation and review of the l...
7446389 - Right ventricular endomyocardial fibrosis simulating ebstein's anomaly.
24076109 - Mycobacterium neoaurum causing prosthetic valve endocarditis: a case report and review ...
23285459 - A malignant transformation in a pre-existing benign scrotal naevus.
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  26     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-08     Completed Date:  2007-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  915-26     Citation Subset:  IM    
Division of Infectious Diseases, University Hospitals of Geneva, 24 Rue Micheli-du-Crest, Geneva 14, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antifungal Agents / therapeutic use
Candida* / classification
Candidiasis / diagnosis,  drug therapy,  microbiology*
Endocarditis / drug therapy,  microbiology*
Reg. No./Substance:
0/Antifungal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evidence of shared risk for Alzheimer's disease and Parkinson's disease using family history.
Next Document:  Chemical composition of the wax secreted by a scale insect (Ceroplastes pseudoceriferus Green).