Document Detail

Candida meningoencephalitis treated with 5-fluorocytosine.
MedLine Citation:
PMID:  841284     Owner:  NLM     Status:  MEDLINE    
The successful treatment of Candida albicans meningoencephalitis with 5-fluorocytosine (5-FC) is reported. After abdominal surgery with many complications, a 60-year-old man developed severe headache, lumbar pain, mental change. The significance of this was not realized for months. The cerebrospinal fluid (CSF) showed pleocytosis, high protein and low glucose concentration. One CSF culture out of 6 revealed growth of Candida albicans. Serologic tests are also indicated candida infection. After a month of treatment with 5-FC, the severe pain decreased and he improved mentally. After 4 months, the CSF was normal and the 5-FC treatment ended. For the past year, the patient has not shown any signs of relapse.
L Nordström; S Oistämö; F Olmebring
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  9     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  1977  
Date Detail:
Created Date:  1977-04-15     Completed Date:  1977-04-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  63-4     Citation Subset:  IM    
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MeSH Terms
Candidiasis / drug therapy*
Cytosine / analogs & derivatives*
Flucytosine / therapeutic use*
Meningoencephalitis / drug therapy*
Middle Aged
Reg. No./Substance:
2022-85-7/Flucytosine; 71-30-7/Cytosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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