Document Detail


Candida isolated from vaginal mucosa of mothers and oral mucosa of neonates: occurrence and biotypes concordance.
MedLine Citation:
PMID:  17596793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The common occurrence of Candida spp. on the vaginal mucosa of pregnant women suggests this as the source of neonatal candidiasis. METHODS: This study investigated the occurrence of yeasts on the vaginal mucosa of 100 mothers at the time of birth, and on the oral mucosa of their respective neonates, all full-term, on the 1st, 3rd, and 9th days after birth by vaginal (72 cases) and cesarean (28 cases) routes. In each case where concordance at the level of species was found between the isolate from the mother and that from the neonate, tests were made to check for concordance between the genotypic and phenotypic profiles (susceptibility to killer toxins, serotyping, proteinase and phospholipase production, and susceptibility to antifungal agents). RESULTS: For the vaginal-route group, yeasts were recovered from the vaginal mucosa of 47.2% of the mothers and from 25% of the neonates. For the cesarean-route group, these rates were 46.4% and 3.6%, respectively. Species found most frequently in the samples from the mothers and the neonates were, respectively C. albicans and C. guilliermondii. For the vaginal-route group, the rate of mother/neonate concordance at the level of species was 23.5% and no cases of concordance for the cesarean births. Of these cases with species concordance, there was concordance between the genotypic and phenotypic profiles in 6% (2 cases). CONCLUSION: The vaginal mucosa was not the main route of transmission of the Candida species to the neonate, because there was concordance between the genotypic and phenotypic profiles in only 6% (2 cases).
Authors:
Dayse Alcará Caramalac; Luciana da Silva Ruiz; Georgea Carla Matuura de Batista; Esther Goldenberg Birman; Miriam Duarte; Rosane Hahn; Claudete Rodrigues Paula
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  26     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-28     Completed Date:  2007-08-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  553-7     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Biomedical Sciences II Institute, São Paulo University, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Candida / classification,  isolation & purification*
Candidiasis / microbiology,  transmission*
Cesarean Section
Female
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Mouth / microbiology
Mucous Membrane / microbiology*
Parturition
Pregnancy
Vagina / microbiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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