| Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. | |
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MedLine Citation:
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PMID: 21569057 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The incidence of infections caused by Candida species (candidosis) has increased greatly over the past three decades, mainly due to the rise of the AIDS epidemic, an increasingly aged population, higher numbers of immunocompromised patients, and the more widespread use of indwelling medical devices. Candida albicans is the main cause of candidosis, however, non-Candida albicans Candida species such as Candida glabrata, Candida tropicalis and Candida parapsilosis are now frequently identified as human pathogens. The apparent increased emergence of these species as human pathogens can be attributed to improved identification methods and also associated with the degree of diseases of the patients, the interventions that they were subjected and with the drugs used. Candida pathogenicity is facilitated by a number of virulence factors, most importantly adherence to host surfaces including medical devices, biofilm formation, and secretion of hydrolytic enzymes (e.g. proteases, phospholipases and haemolysins). Furthermore, despite extensive research to identify pathogenic factors in fungi, particularly in C. albicans, relatively little is known about non-Candida albicans Candida species. This review provides information on the current state of knowledge on the biology, identification, epidemiology, pathogenicity and antifungal resistance of C. glabrata, C. parapsilosis and C. tropicalis. |
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Authors:
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Sónia Silva; Melyssa Negri; Mariana Henriques; Rosário Oliveira; David W Williams; Joana Azeredo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-13 |
Journal Detail:
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Title: FEMS microbiology reviews Volume: - ISSN: 1574-6976 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902526 Medline TA: FEMS Microbiol Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
Affiliation:
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Institute for Biotechnology and Bioengineering, Universidade do Minho, Campus de Gualtar 4710-057, Braga, Portugal Tissue Engineering & Reparative Dentistry, School of Dentistry, Heath Park, Cardiff, CF14 4XY, UK. |
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